A search and evaluation of the peptides that control the connective tissue growth factor for the prevention and the treatment of osteoarthritis.
Project/Area Number |
24792142
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Okayama University |
Principal Investigator |
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Research Collaborator |
KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 教授
SONOYAMA Wataru 岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 講師
ONO Mitsuaki 岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 助教
ハラ エミリオ サトシ 岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 助教
SHINKAWA Shigehiko 岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 医員
NAKAJIMA Ryu 岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 大学院生
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ハルミン / CCN2 / β-カルボリン / 軟骨細胞 / 軟骨再生 / Harmine / 変形性関節症 / 軟骨分化 / 結合組織成長因子 CTGF |
Research Abstract |
CCN2 / connective tissue growth factor (CTGF) has been reported to have essential role in cartilage development, chondrocyte proliferation and differentiation as well as regulation of the extracellular matrix metabolism. This study screened a compound library and identified harmine as a novel inducer of CCN2. This finding indicates harmine as a potential drug for prevention and / or repair of cartilage degradation.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Novel chondrogenic and chondroprotective effects of the natural compound harmine.2013
Author(s)
Hara, E. S., Ono, M., Kubota, S., Sonoyama, W., Oida, Y., Hattori, T., Nishida, T., Furumatsu, T., Ozaki, T., Takigawa, M. and Kuboki, T
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Journal Title
Biochimie
Volume: 95
Issue: 2
Pages: 347-381
DOI
Related Report
Peer Reviewed
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[Presentation] The CCN2-inducer Harmine promotes chondrogenesis and protection against TNFα-induced inflammation2011
Author(s)
Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
Organizer
第59 国際歯科研究学会日本部会 (JADR) 総会・学術大会- Hatton award competition
Place of Presentation
Hiroshima, Japan
Year and Date
2011-10-08
Related Report
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[Presentation] The CCN2-inducer Harmine promotes chondrogenesis and protection against TNFα-induced inflammation2011
Author(s)
Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
Organizer
第59国際歯科研究学会日本部会 (JADR) 総会・学術大会
Place of Presentation
Hiroshima, Japan
Year and Date
2011-10-08
Related Report
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[Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and rescues TNF-α-induced downregulation of cartilage markers2011
Author(s)
Hara ES, Ono M, Kubota S, Sonoyama W, Hattori T, Nishida T, Takigawa M, Kuboki T
Organizer
第2骨バイオサイエンス研究会
Place of Presentation
Okayama, Japan
Year and Date
2011-08-28
Related Report
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[Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and protection against TNF-α-induced inflammatory condition2011
Author(s)
Hara ES, Ono M, Kubota S, Sonoyama W, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
Organizer
第4日本CCNファミリー研究会
Place of Presentation
Okayama, Japan
Year and Date
2011-08-28
Related Report
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