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Basic study on the action mechanism of low-energy laser: Control of free radicals

Research Project

Project/Area Number 24792150
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionOhu University

Principal Investigator

MORO YURIKO  奥羽大学, 歯学部, 助教 (90433549)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords低出力レーザー / 血管内皮細胞 / フリーラジカル / In vitro / 炎症 / 活性酸素 / 一酸化窒素
Outline of Final Research Achievements

To investigate the influence of low-energy laser on the free radical control system, dynamics of nitric oxide, reactive oxygen, reactive oxygen-scavenging enzyme, and nitrotyrosine in vascular endothelial cells were observed. Laser irradiation changed these free radical expressions, and the expression in the inflammatory state was different from that in the non-inflammatory state. It was suggested that low-energy laser influences free radical expression, contributing to the anti-inflammatory effect.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2016 2014 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] 低出力レーザーによる血管内皮細胞における抗炎症作用-活性酸素発現に及ぼす影響-2016

    • Author(s)
      茂呂 祐利子、原田 卓哉、渡部 剛史
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島県・郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 低出力レーザーの血管内皮細胞に対する抗炎症作用2014

    • Author(s)
      茂呂祐利子、渡部剛史、原田卓哉、鈴木陽典
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(栃木県下野市)
    • Related Report
      2013 Research-status Report
  • [Remarks] 奥羽大学報141号

    • URL

      http://www.ohu-u.ac.jp/etc/newsletter.html

    • Related Report
      2014 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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