Clarification of mechanisms of metastasis suppression centered around DPT, extracellular matrix protein in oral cancer

• Project/Area Number: 24792174
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: University of Tsukuba
• Principal Investigator: YAMATOJI Masanobu 筑波大学, 附属病院, 医員 (70451747)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Dermatopontin / microRNA / 口腔がん / 臨床腫瘍学

Outline of Final Research Achievements

Dermatopontin (DPT) which exists extracellular matrix was significantly down-regulated and was indicated its expression related to cancer metastasis. We tried to find out microRNA which controls DPT expression and yields a clue of cancer metastasis. As a result, several kinds of microRNA was picked out in oral cancer, but microRNA which changes DPT expression wasn't seen in those.