Objective diagnostic procedure of the microinvasion of the oral mucosal malignancies
| Project/Area Number |
24792186
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 口腔癌 / 初期浸潤 / 上皮内癌 / 異型上皮 / 術中迅速診断 / 再発 / 初期浸潤癌 / 細胞外基質 / ヘパラン硫酸プロテオグリカン / ラミニン / IV型コラゲン / テネイシン |
|---|
| Research Abstract |
It is difficult to determine the early microinvasion of oral squamous cell carcinoma histopathologically. Therefore we focused the production and deposition of the extracellular matrix (ECM), and investigated whether there was characteristic ECM deposition in the oral invasive cancer.
As a result, the thickening of basement membrane was characteristic in the carcinoma in-situ (CIS), and excessive deposition of basement membrane molecules at the thickening zone were confirmed immunohistochemically. Furthermore, ECM molecules, especially perlecan, were deposited in the epithelial layers of the epithelial dysplasia and CIS, whereas their deposition switched into the cancer stroma at the invasive stage.
In conclusion, the switching of area of ECM deposition could be regarded as an indicator of early invasion of oral cancer.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma2013
Author(s)
Nagata M, Noman AA, Suzuki K, Kurita H, Ohnishi M, Ohyama T, Kitamura N, Kobayashi T, Uematsu K, Takahashi K, Kodama N, Kawase T, Hoshina H, Ikeda N, Shingaki S, Takagi R
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Journal Title
BMC Cancer
Volume: 13
Pages: 410-410
Related Report
Peer Reviewed
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[Journal Article] Inflammatory histopathogenesis of nasopalatine duct cyst : a clinicopathological study of 41 cases2013
Author(s)
Tsuneki M, Maruyama S, Yamazaki M, Abe T, Adeola HA, Cheng J, Nishiyama H, Hayashi T, Kobayashi T, Takagi R, Funayama A, Saito C, Saku T
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Journal Title
Oral disease
Volume: 19
Pages: 415-424
Related Report
Peer Reviewed
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[Journal Article] ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma.2013
Author(s)
Nagata M, Noman AA, Suzuki K, Kurita H, Ohnishi M, Ohyama T, Kitamura N, Kobayashi T, Uematsu K, Takahashi K, Kodama N, Kawase T, Hoshina H, Ikeda N, Shingaki S, Takagi R
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Journal Title
BMC Cancer
Volume: 13
Issue: 1
Pages: 410-410
DOI
Related Report
Peer Reviewed
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[Journal Article] Short telomeres in an oral precancerous lesion : Q-FISH analysis of leukoplakia2012
Author(s)
Aida J, Kobayashi T, Saku T , Yamaguchi M, Shimomura N, Nakamura K, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, Arai T, Takubo K
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Journal Title
J Oral Pathology and Medicine
Volume: 41(5)
Pages: 372-378
Related Report
Peer Reviewed
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[Journal Article] 頭頸部癌の切除不能頸部リンパ節転移巣に対する温熱化学放射線療法, 治療成績および予後について2012
Author(s)
星名秀行, 永田昌毅, 高木律男, 藤田 一, 安島久雄, 児玉泰光, 池田順行, 齋藤正直, 小林孝憲, 嵐山貴徳, 小山貴寛, 小玉直樹, 勝見祐二, 小川 信, 山田一穂, 魚島勝美
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Journal Title
新潟歯学会誌
Volume: 42(1)
Pages: 27-36
Related Report
Peer Reviewed
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[Journal Article] Short telomeres in an oral precancerous lesion : Q-FISH analysis of leukoplakia2012
Author(s)
Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura KI, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, aida T, Takubo K.
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Journal Title
Journal of Oral Pathology & Medicine
Volume: 41(5)
Issue: 5
Pages: 372-378
DOI
Related Report
Peer Reviewed
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