Evaluation mesenchymal stem cell conditioned medium for prevention of oral mucositis
| Project/Area Number |
24792199
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
FURUE Hiroki 名古屋大学, 医学部附属病院, 助教 (40567012)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 放射線口内炎 / 口腔癌 / 放射線治療 |
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| Research Abstract |
Oral mucosits is the major side effect by radiation therapy for oral cancer. Today there is no efficient and safe therapeutic solution for oral mucositis. Our earlier studies showed that mesenchymal stem cell-conditioned medium(CM) contains many growth factors derived from stem cells, and accelerate skin wound healing. Therefore we investigated the treatment effect of CM on oral mucositis. First, rats were used for pathological assessment. Rats were treated with mouth radiation alone or in combination with CM. 5 weeks after radiation, tongue specimens were collected. There is no significant difference between radiation alone and CM. Next, for investigating the anti-inflammatory effect of the CM, some inflammatory cytokines were assayed by q-PCR or ELISA by using other animal model of inflammatory disorder. In the result, expression level of some cytokines were reduced by CM. Further studies on the mechanism of CM to protect oral mucosits by radiation therapy are needed.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma2013
Author(s)
Hagiwara S, Yamamoto N, Furue H, Sakakura H, Shigetomi T, Murakumo Y, Hibi H, Takahashi M, Ueda M
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 25
Issue: 3
Pages: 276-287
DOI
Related Report
Peer Reviewed
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[Presentation] 愛知県がんセンターの取り組み2013
Author(s)
古江浩樹, 西川雅也, 澤村昌嗣, 市村典久, 阿部厚, 吉岡文, 長縄弥生, 高松磨由子, 山本憲幸, 栗田賢一, 上田実, 長谷川泰久
Organizer
第30回東海頭頸部腫瘍研究会
Place of Presentation
名古屋市 ウインク愛知
Year and Date
2013-02-02
Related Report
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