| Project/Area Number |
24792213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
SHIBATA Akane 岡山大学, 大学院, 大学院生
KUWAJIMA Daisuke 岡山大学, 大学院, 大学院生
MORISAWA Ayaka 岡山大学, 大学院, 大学院生
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | リンパ管新生 / 血管新生 |
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| Research Abstract |
ANG plays a significant role in angiogenesis. Lymphoedema is a refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether ANG promotes lymphangiogenesis and improves lymphoedema. Administration of ANG and VEGF-C to mice with tail lymphoedema resulted in a decrease in lymphoedema thickness. ANG and VEGF-C treatment increased the number of lymphatic vessels in the injury site.The effects of ANG and VEGF-C on lymphatic endothelial cells were investigated. ANG and VEGF-C promoted ANG nuclear translocation and cell proliferation in lymphatic endothelial cells. Angiogenin-induced lymphangiogenesis is a possible new therapeutic strategy for lymphoedema.
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