New therapeutic target associated with epigenetic changes with epithelial-mesenchymal transition of oral cancer
Project/Area Number |
24792255
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Showa University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 口腔扁平上皮癌 / 上皮間葉移行 / DNAメチル化 / 口腔癌 / エピジェネティクス |
Outline of Final Research Achievements |
We were able to induce the epithelial-mesenchymal transition and (EMT) by TGF-β stimulation in oral squamous cell carcinoma cells. It induces EMT by TGF-β stimulation, and the attenuation of E-cadherin, enhancement of N-cadherin could be confirmed. From exhaustive DNA methylation analysis, we identified GPR-37 as a gene that is induced methylation, and LOM2 and PALLD as genes that are induced hypomethylation by transfoemation change by EMT.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] Epigenomic profiling of oral cancer2012
Author(s)
Sayaka Yoshiba, Genta Nagae, Atsushi Kaneda, Shingo Tsuji, Keisuke Matsusaka, Koichi Yagi, Takayuki Isagawa, Tetsuhiko Tachikawa, Satoru Shintani, Hiroyuki Aburatani
Organizer
AACR Annual Meeting 2012
Place of Presentation
アメリカ シカゴ
Related Report
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