| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
All of the mAchR family were expressed in MPDL22 at the mRNA level. Carpronium chrolide treatment enhanced the ALP activity and expression of ossification related genes, such as Runx2, Osterix, ALP, Collagen type I, Osteocalcin, Osteopontin, and Osteonectin, in the period of long term ossification culture. Furthermore, Carpronium chloride promoted calcified nodule formation of MPDL22 cells. In addition, it was confirmed that carpronium chrolide accelerated the tube formation of HUVECs on matrigel.These data suggest that application of carpronium chrolide on periodontal disease could stimulate periodontal tissue regeneration.
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