| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We analyzed the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of insulin-like growth factor I (IGF-I). rats were subjected to right mandibular first molar extraction. Experimental rats received a continuous subcutaneous infusion of IGF-I by minipump. Control animals were treated with saline via the same method. All rats were then housed after stop of the infusion. Micro-CT scanning was performed immediately after tooth extraction and at regular intervals.
New bone formation was markedly higher in the IGF-I-treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side. IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction.
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