Are salivary stress-related biomarkers available as indicators of xerostomia?

• Project/Area Number: 24792350
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Niigata University
• Principal Investigator: NOHNO Kaname 新潟大学, 医歯学総合病院, 助教 (80422608)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯学 / 口腔乾燥

Outline of Final Research Achievements

Psychological stress causes a reduction of salivary flow, it is necessary to assess the stress on diagnosis of xerostomia. There are stress-related biomarkers in saliva. The purpose of this study was to evaluate a correlation between the reduction of salivary flow and salivary stress-related biomarkers. In conclusion, we found a possibility of correlation between stimulated salivary flow and salivary IgA. However, we didn’t find statistically significant correlations of amount nor change ratios between salivary flow and stress-related biomarkers.