| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We analyzed the effects of tumor endothelial cells on tumor cells in tumor metastasis. In vivo analysis showed that highly metastatic tumor derived endothelial cells could promote tumor metastasis. We found some genes were upregulated in highly metastatic tumor-derived endothelial cells. When the genes were knocked down, tumor metastasis promoted by tumor endothelial cells described above was cancelled. Furthermore, the expression of the molecules in tumor blood vessels was confirmed in human clinical samples. These data suggested that the molecules which were upregulated in highly metastatic tumor-derived endothelial cells were involved in tumor metastasis.
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