Elucidation of involvement of tumor blood vessel in tumor metastasis and regulation of tumor metastasis
| Project/Area Number |
24890007
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
MAISHI Nako 北海道大学, 歯学研究科(研究院), 特任助教 (00632423)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 転移 / 腫瘍血管 |
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| Research Abstract |
We analyzed the effects of tumor endothelial cells on tumor cells in tumor metastasis. In vivo analysis showed that highly metastatic tumor derived endothelial cells could promote tumor metastasis. We found some genes were upregulated in highly metastatic tumor-derived endothelial cells. When the genes were knocked down, tumor metastasis promoted by tumor endothelial cells described above was cancelled. Furthermore, the expression of the molecules in tumor blood vessels was confirmed in human clinical samples. These data suggested that the molecules which were upregulated in highly metastatic tumor-derived endothelial cells were involved in tumor metastasis.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells2014
Author(s)
Otsubo T., et al., Hida Y., Ohga N., Sato H., Kai T., Matsuki Y., Takasu H., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Nonomura K., Hida K.
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Journal Title
Cancer Sci.
Volume: (印刷中)
Issue: 5
Pages: 560-567
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lysyl oxidase secreted by tumour endothelial cells Promotes angiogenesis and metastasiso2013
Author(s)
Osawa T., et al., Ohga N., Akiyama K., Hida Y., Kitayama K., Kawamoto T, , Yamamoto K., Maishi N., Kondoh M., Onodera Y., Fujie M., Nonomura K., Shindoh M., Hida K.
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Journal Title
Br. J. Cancer
Volume: 109(8)
Issue: 8
Pages: 2237-2247
DOI
Related Report
Peer Reviewed
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[Journal Article] The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma2013
Author(s)
Akiyama K., Ohga N., Maishi N., Hida Y., Kitayama K., Kawamoto T., Osawa T., Suzuki Y., Shinohara N., Nonomura K., Shindoh M., Hida K.
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Journal Title
Pathol. Int.
Volume: 63(1)
Issue: 1
Pages: 37-44
DOI
Related Report
Peer Reviewed
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