Neutrophil-mediated anaphylaxis-like shock in mice
| Project/Area Number |
24890022
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TANAKA Yukinori 東北大学, 歯学研究科(研究院), 助教 (60637958)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アナフィラキシー / 好中球 / 免疫学 |
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| Research Abstract |
Complement C5a is known as a classical anaphylatoxin, capable of stimulating the secretion of histamine from mast cells. Injection of C5a induced fatal anaphylaxis-like shock in mice pretreated with lipopolysaccharide. On the other hand, injection of C5a alone caused hypothermia, a symptom of murine systemic anaphylaxis, which was not fatal. Surprisingly, anaphylaxis-like shock induced by lipopolysaccharide plus C5a depended on basophils, neutrophils, and histamine, but not on mast cells. These results indicate that pre-existing bacterial infection may augment systemic anaphylaxis by activating neutrophils.
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Report
(3 results)
Research Products
(10 results)
