Antifibrotic effect and role of antibody to connective tissue growth factor in an animal model of scleroderma

• Project/Area Number: 24890076
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kanazawa University
• Principal Investigator: CHUJO Sonoko 金沢大学, 大学病院, 助教 (20401911)
• Project Period (FY): 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 強皮症 / 線維化 / CTGF

Research Abstract

We investigated antifibrotic effect of antibody to connective tissue growth factor (CTGF) in an animal model of skin fibrosis. Anti-CTGF antibody reduced skin fibrosis in a bleomycin-induced scleroderma mouse model and a tight skin mouse. It suggested that anti-CTGF antibody is capable of blocking the development of skin fibrosis in an animal model not induced by exogenous application of growth factors.