Mechanism of activation of ryanodine receptor by diamide insecticide
| Project/Area Number |
24890091
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kyoto University |
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Principal Investigator |
KUROKAWA Tatsuki 京都大学, 工学(系)研究科(研究院), 助教 (40527701)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | リアノジン受容体 / 昆虫 / 農薬 |
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| Research Abstract |
Flubendiamide shows selective insecticidal activity against lepidopterous insects. The ryanodine receptor (RyR) Ca2+ release channel is a primary target of flubendiamide. However, the molecular mechanisms underlying the species-specific action of flubendiamide are unclear. To identify the flubendiamide-binding region within RyR, we used new affinity probe and LC/MS/MS analysis. The results suggest that the flubendiamide response of RyR requires the diversity region 1. Our findings provide important information for understanding the species-selective effects of flubendiamide.
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Report
(3 results)
Research Products
(21 results)
