Development of novel periodontal tissue regenerative therapy by small molecule ligands induced TrkB transactivation

• Project/Area Number: 24890142
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Hiroshima University
• Principal Investigator: MIKIHITO Kajiya 広島大学, 大学病院, 助教 (00633041)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 再生医療 / BDNF / TrkB / ERK / セメント芽細胞

Research Abstract

It is previously reported that Brain-derived neurotrophic factor (BDNF) stimulates cementoblast differentiation via its high affinity receptor, TrkB. In this present study, an applicant have discovered that small molecule BDNF mimetic, LM22A-4, also activates TrkB signaling cascade in cementoblast.
This result has been published in International Immunopharmacology.

Research Products

• [Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/AKt signaling cascade (2014)
  • Author(s): Mikihito Kajiya, Kei Takeshita, Mizuho Kittaka, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba, and Hidemi Kurihara
  • Journal Title: International Immunopharmacology Volume: 19 Pages: 245-252
  • Peer Reviewed
• [Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade. (2014)
  • Author(s): Kajiya M, Takeshita K, Kittaka M, Matsuda S, Ouhara K, Takeda K, Takata T, Kitagawa M, Fujita T, Shiba H, Kurihara H
  • Journal Title: Int Immunopharmacol Volume: 19(2) Issue: 2 Pages: 245-52
  • DOI: 10.1016/j.intimp.2014.01.028
  • Peer Reviewed
• [Presentation] 低分子BDNF模倣化合物LM22A-4はTrkBシグナルを介してセメント芽細胞の分化を制御する (2013)
  • Author(s): 加治屋幹人、柏井圭、竹下慶、Nguyen Quoc Troung、高田隆、北川雅恵、藤田剛、柴秀樹、栗原英見
  • Organizer: 日本歯科保存学会2013年度春季学術大会(第139回)
  • Place of Presentation: 福岡、日本
  • Year and Date: 2013-06-27
• [Presentation] Small Molecule BDNF mimetic regulates cementoblast differentiation via TrkB signaling (2013)
  • Author(s): Mikihito Kajiya, Hideki Shiba, Kazuhisa Ouhara, Katsuhiro Takeda, Mizuho Kittaka, Takashi Takata, Masae Kitagawa, Hidemi Kurihara
  • Organizer: International Association of Dental Research
  • Place of Presentation: Seattle, USA
  • Year and Date: 2013-03-20
• [Presentation] 低分子BDNF模倣化合物LM22A-4はTrkBシグナルを介して セメント芽細胞の分化を制御する (2013)
  • Author(s): 加治屋幹人, 柏井 桂, 竹下 慶, Nguyen Quon Trung, 高田 隆, 北川雅恵, 藤田 剛, 柴 秀樹, 栗原英見
  • Organizer: 日本歯科保存学会 2013年度春季学術大会 （138回）
  • Place of Presentation: 福岡
• [Presentation] Small molecule BDNF mimetic regulates cementoblast differentiation via TrkB signaling (2013)
  • Author(s): Mikihito Kajiya
  • Organizer: International Association of Dental Research
  • Place of Presentation: USA Seattle