The study on mechanism elucidation for the effects of small vibration stimuli on bone formation

Research Project

Project/Area Number	24890162
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Prosthetic dentistry
Research Institution	Kyushu University
Principal Investigator	KONO Takashi 九州大学, 大学病院, 医員 (70636068)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	インプラント / 振動刺激 / 骨形成促進 / メカニカルストレス
Research Abstract	The effects of small vibration stimuli on bone formation have been reported. The present in vitro study assessed the effect of low-magnitude, high-frequency (LMHF) vibration stimuli for bone formation on gene expression. In the rat osteoblast-like cells, LMHF vibration stimuli can enhance the bone formation by increasing some factors which accelerate bone formation and decreasing the factor which inhibits bone formation. However, in the mouse osteocyte (MLO-Y4), no gene significantly changed between control group and vibration group.

Report

(3 results)