The role and new therapeutic strategy of autophagy in pancreatic cancer.

• Project/Area Number: 24890172
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: HASHIMOTO Daisuke 熊本大学, 医学部附属病院, 助教 (80508507)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: オートファジー / 膵癌 / 5-FU / ゲムシタビン / クロロキン

Research Abstract

Autophagy is a regulated process of degradation and recycling of cellular constituents. We showed that autophagy is up-regulated in human pancreatic cancer and contributes to pancreatic cancer cell growth, and has a cytoprotective effect against anti-cancer drug in pancreatic cancer cells. Combination therapy of these anticancer drugs and chloroquine should be investigated.

Research Products

• [Journal Article] Impact of Postoperative Weight Loss on Survival After Resection for Pancreatic Cancer (2014)
  • Author(s): Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H
  • Journal Title: JPEN J Parenter Enteral Nutr
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/24486859
  • Peer Reviewed
• [Journal Article] Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs (2014)
  • Author(s): Hashimoto D, Bläuer M, Hirota M, Ikonen NH, Sand J, Laukkarinen J
  • Journal Title: Eur J Cancer Volume: 50(7) Issue: 7 Pages: 1382-90
  • DOI: 10.1016/j.ejca.2014.01.011
  • Peer Reviewed
• [Journal Article] Impact of postoperative weight loss on survival after resection for pancreatic cancer. (2014)
  • Author(s): Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H.
  • Journal Title: J Parenter Enteral Nutr. Volume: Epub ahead of print Issue: 5 Pages: 598-603
  • DOI: 10.1177/0148607114520992
  • Peer Reviewed
• [Journal Article] End-to-side pancreaticojejunostomy without stitches in the pancreatic stump (2013)
  • Author(s): Hashimoto D, Hirota M, Yagi Y, Baba H
  • Journal Title: Surg Today Volume: 43(7) Issue: 7 Pages: 821-4
  • DOI: 10.1007/s00595-012-0371-x
  • NAID: 10031183398
  • Peer Reviewed
• [Journal Article] Hyaluronate carboxymethylcellulose-based bioresorbable membrane (Seprafilm) reduces adhesion under the incision to make unplanned re-laparotomy safer (2012)
  • Author(s): Hashimoto D, Hirota M, Yagi Y, Baba H
  • Journal Title: Surg Today Volume: 42(9) Issue: 9 Pages: 863-7
  • DOI: 10.1007/s00595-012-0191-z
  • NAID: 10031032419
  • Peer Reviewed
• [Journal Article] Clinical features of strangulated small bowel obstruction (2012)
  • Author(s): Hashimoto D, Hirota M, Matsukawa T, Yagi Y, Baba H
  • Journal Title: Surg Today Volume: 42(11) Issue: 11 Pages: 1061-5
  • DOI: 10.1007/s00595-012-0207-8
  • NAID: 10031120767
  • Peer Reviewed
• [Journal Article] Distal pancreatectomy using a no-touch isolation technique (2012)
  • Author(s): Hirota M, Hashimoto D, Ishiko T, Satoh N, Takamori H, Chikamoto A, Tanaka H, Sugita H, Sand J, Nordback I, Baba H
  • Journal Title: Scand J Surg Volume: 101(3) Pages: 156-9
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=Distal+pancreatectomy+using+a+no-touch+isolation+technique
  • Peer Reviewed
• [Journal Article] Distal pancreatectomy using a no-touch isolation technique (2012)
  • Author(s): Masahiko Hirota, Hiroki Sugita
  • Journal Title: Scand J Surg Volume: 101 Issue: 3 Pages: 156-159
  • DOI: 10.1177/145749691210100303
  • Peer Reviewed
• [Presentation] Johanna Laukkarinen. Autophagy in BxPC-3 human pancreatic cancer cells is similar to PANC-1 when treated with anticancer drugs and inhibitors of autophagy (2013)
  • Author(s): Hashimoto D, Merja Bläuer, Juhani Sand, Masahiko Hirota
  • Organizer: The 45th Annual Meeting of the European Pancreatic Club
  • Place of Presentation: Zurich, Switzerland
  • Year and Date: 2013-06-27
• [Presentation] 膵癌におけるオートファジーの役割と癌治療への応用 (2012)
  • Author(s): 橋本大輔
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2012-10-25
• [Presentation] 膵癌におけるオートファジーの役割と癌治療への応用 (2012)
  • Author(s): 橋本 大輔
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Autophagy in BxPC-3 human pancreatic cancer cells is similar to PANC-1 when treated with anticancer drugs and inhibitors of autophagy.
  • Author(s): Hashimoto D, Merja Bläuer, Juhani Sand, Masahiko Hirota, Johanna Laukkarinen
  • Organizer: The 45th European Pancreatic Club
  • Place of Presentation: Zurich,Switzerland
• [Book] Autophagy in Pancreatic Diseases. Pancreas : Anatomy, Diseases and Health Implications (2012)
  • Author(s): Hashimoto D
  • Total Pages: 19
  • Publisher: Nova Science Publishers, Inc. (USA)
• [Book] Autophagy in Pancreatic Diseases. Pancreas: Anatomy, Diseases and Health Implications. (2012)
  • Author(s): Hashimoto D
  • Total Pages: 19
  • Publisher: Nova Science Publishers, Inc. (USA)