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The role and new therapeutic strategy of autophagy in pancreatic cancer.

Research Project

Project/Area Number 24890172
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

HASHIMOTO Daisuke  熊本大学, 医学部附属病院, 助教 (80508507)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsオートファジー / 膵癌 / 5-FU / ゲムシタビン / クロロキン
Research Abstract

Autophagy is a regulated process of degradation and recycling of cellular constituents. We showed that autophagy is up-regulated in human pancreatic cancer and contributes to pancreatic cancer cell growth, and has a cytoprotective effect against anti-cancer drug in pancreatic cancer cells. Combination therapy of these anticancer drugs and chloroquine should be investigated.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Impact of Postoperative Weight Loss on Survival After Resection for Pancreatic Cancer2014

    • Author(s)
      Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H
    • Journal Title

      JPEN J Parenter Enteral Nutr

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/24486859

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs2014

    • Author(s)
      Hashimoto D, Bläuer M, Hirota M, Ikonen NH, Sand J, Laukkarinen J
    • Journal Title

      Eur J Cancer

      Volume: 50(7) Issue: 7 Pages: 1382-90

    • DOI

      10.1016/j.ejca.2014.01.011

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of postoperative weight loss on survival after resection for pancreatic cancer.2014

    • Author(s)
      Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H.
    • Journal Title

      J Parenter Enteral Nutr.

      Volume: Epub ahead of print Issue: 5 Pages: 598-603

    • DOI

      10.1177/0148607114520992

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] End-to-side pancreaticojejunostomy without stitches in the pancreatic stump2013

    • Author(s)
      Hashimoto D, Hirota M, Yagi Y, Baba H
    • Journal Title

      Surg Today

      Volume: 43(7) Issue: 7 Pages: 821-4

    • DOI

      10.1007/s00595-012-0371-x

    • NAID

      10031183398

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyaluronate carboxymethylcellulose-based bioresorbable membrane (Seprafilm) reduces adhesion under the incision to make unplanned re-laparotomy safer2012

    • Author(s)
      Hashimoto D, Hirota M, Yagi Y, Baba H
    • Journal Title

      Surg Today

      Volume: 42(9) Issue: 9 Pages: 863-7

    • DOI

      10.1007/s00595-012-0191-z

    • NAID

      10031032419

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of strangulated small bowel obstruction2012

    • Author(s)
      Hashimoto D, Hirota M, Matsukawa T, Yagi Y, Baba H
    • Journal Title

      Surg Today

      Volume: 42(11) Issue: 11 Pages: 1061-5

    • DOI

      10.1007/s00595-012-0207-8

    • NAID

      10031120767

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distal pancreatectomy using a no-touch isolation technique2012

    • Author(s)
      Hirota M, Hashimoto D, Ishiko T, Satoh N, Takamori H, Chikamoto A, Tanaka H, Sugita H, Sand J, Nordback I, Baba H
    • Journal Title

      Scand J Surg

      Volume: 101(3) Pages: 156-9

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=Distal+pancreatectomy+using+a+no-touch+isolation+technique

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distal pancreatectomy using a no-touch isolation technique2012

    • Author(s)
      Masahiko Hirota, Hiroki Sugita
    • Journal Title

      Scand J Surg

      Volume: 101 Issue: 3 Pages: 156-159

    • DOI

      10.1177/145749691210100303

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Johanna Laukkarinen. Autophagy in BxPC-3 human pancreatic cancer cells is similar to PANC-1 when treated with anticancer drugs and inhibitors of autophagy2013

    • Author(s)
      Hashimoto D, Merja Bläuer, Juhani Sand, Masahiko Hirota
    • Organizer
      The 45th Annual Meeting of the European Pancreatic Club
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2013-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵癌におけるオートファジーの役割と癌治療への応用2012

    • Author(s)
      橋本大輔
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵癌におけるオートファジーの役割と癌治療への応用2012

    • Author(s)
      橋本 大輔
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Autophagy in BxPC-3 human pancreatic cancer cells is similar to PANC-1 when treated with anticancer drugs and inhibitors of autophagy.

    • Author(s)
      Hashimoto D, Merja Bläuer, Juhani Sand, Masahiko Hirota, Johanna Laukkarinen
    • Organizer
      The 45th European Pancreatic Club
    • Place of Presentation
      Zurich,Switzerland
    • Related Report
      2013 Annual Research Report
  • [Book] Autophagy in Pancreatic Diseases. Pancreas : Anatomy, Diseases and Health Implications2012

    • Author(s)
      Hashimoto D
    • Total Pages
      19
    • Publisher
      Nova Science Publishers, Inc. (USA)
    • Related Report
      2013 Final Research Report
  • [Book] Autophagy in Pancreatic Diseases. Pancreas: Anatomy, Diseases and Health Implications.2012

    • Author(s)
      Hashimoto D
    • Total Pages
      19
    • Publisher
      Nova Science Publishers, Inc. (USA)
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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