| Project/Area Number |
24890237
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 胚子ヘモグロビン / 重症貧血 / ヘモグロビン発現制御因子 / 窒素含有型ビスホスホネート / 髄外造血 / 血リンパ節様構造 / HIF1a / 転写制御因子ＫＬＦ / 肝臓 |
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| Research Abstract |
Mammal hematopoiesis occurs two distinct waves, kwon as a primitive and definitive; and to express the hemoglobin of different types are known. However, there is no possibility that the hematopoietic system of these two simultaneous presence in the adult.
We established an experimental system to re-express the embryonic hemoglobin in adult mice by inducing the critical anemia treated with nitrogen containing bisphosphonate and phenylhydrazine, and we detected the cell, expressing at the same time the erythroid marker and embryonic hemoglobin in the liver. We also confirmed that the hemoglobin subunites of adult and embryo types were simultaneously present in the peripheral blood. In addition, it was possible to confirm the factors, which regulates the expression and switching of hemoglobin. These results support that understanding the mechanism of hemoglobin expression and switching during development.
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