| Project/Area Number |
24890251
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
SAIJO Hiroki 東京慈恵会医科大学, 医学部, 大学院博士課程 4 年生
|
|---|
| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 内耳 / 卵形嚢 / 有毛細胞 / 再生 |
|---|
| Research Abstract |
We found that neural crest cells spontaneously regenerate the utricle hair cells. We performed the utricle organ culture using GFP mice labeling neural crest cells. After completely lost the hair bundles, the utricles were subsequently cultured for 14 days. GFP positive cells were existed in the sensory epithelia of the cultured utricles. A part of GFP positive cells expressed Myosin VIIa, a utricle hair cell marker, in the utricle sensory epithelia. These results revealed that neural crest cells compose the utricle hair cells regenerated spontaneously.
|
