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Tau aggregation regulated by membrane lipid

Research Project

Project/Area Number 24890305
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

SUMIOKA Akio  独立行政法人国立長寿医療研究センター, 分子基盤研究部, 室長 (00431320)

Co-Investigator(Renkei-kenkyūsha) GOTO Asako  国立長寿医療研究センター, 研究員 (90455460)
TAKASHIMA Akihiko  国立長寿医療研究センター, 部長 (00154774)
Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経科学 / 生化学 / 認知症 / 脳神経疾患 / 脂質
Research Abstract

Aggregation of Tau protein would be one of the causative factor for Alzheimer's Disease (AD). In this study, I addressed a role of membrane lipid for Tau aggregation.
I examined an interaction between Tau and lipid bilayer. In a result, I identified lipid X1 as a specific interactor of Tau protein. Furthermore I reveal a mechanism of the interaction by using Tau mutants. Then I examine the effect of lipid X1 on Tau pathology by ThT assay, and I found that X1 strongly inhibit their aggregation.
Interestingly, it is reported that lipid X1 is decreased in AD patients. These finding potentially suggest hypothesis that abnormal lipid metabolism would undergo neurodegeneration through Tau pathology.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (4 results)

All 2013 Other

All Presentation (2 results) Remarks (2 results)

  • [Presentation] タウ結合分子(膜脂質によるTau病変制御モデルの検証)2013

    • Author(s)
      住岡暁夫
    • Organizer
      タウ研究ミーティング
    • Place of Presentation
      大府
    • Year and Date
      2013-08-09
    • Related Report
      2013 Final Research Report
  • [Presentation] タウ結合分子 (膜脂質によるTau病変制御モデルの検証)2013

    • Author(s)
      住岡暁夫
    • Organizer
      タウ研究ミーティング
    • Place of Presentation
      大府市健康プラザ
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncgg.go.jp/department/nba/sumi.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 標的治療開発室 | 国立長寿医療研究センター【分子基盤研究部】

    • URL

      http://www.ncgg.go.jp/department/nba/sumi.html

    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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