| Budget Amount *help |
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2015: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2014: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2013: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Outline of Final Research Achievements |
Through the analysis of hepatitis B virus envelope protein, we have identified the following novel functional domains: active targeting domain, stealth domain, and cell invasion domain. By displaying these domains as synthetic peptide, the artificial and conventional DDS carriers could function as next-gen DDS carrier that functions like hepatitis B virus. Furthermore, in other viruses, we have identified similar functional domains in their envelope proteins. These results strongly suggested that various next-gen DDS carriers could be generated by this strategy.
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