2016 Fiscal Year Final Research Report
Development of next-gen DDS carrier by utilizing virus envelope-derived functional domains
Project/Area Number |
25242043
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
|
Research Institution | Osaka University (2015-2016) Nagoya University (2013-2014) |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | DDS / ウイルス / ナノキャリア |
Outline of Final Research Achievements |
Through the analysis of hepatitis B virus envelope protein, we have identified the following novel functional domains: active targeting domain, stealth domain, and cell invasion domain. By displaying these domains as synthetic peptide, the artificial and conventional DDS carriers could function as next-gen DDS carrier that functions like hepatitis B virus. Furthermore, in other viruses, we have identified similar functional domains in their envelope proteins. These results strongly suggested that various next-gen DDS carriers could be generated by this strategy.
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Free Research Field |
分子細胞生物学
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