Development of next-gen DDS carrier by utilizing virus envelope-derived functional domains
Project/Area Number |
25242043
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Osaka University (2015-2016) Nagoya University (2013-2014) |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2015: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2014: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2013: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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Keywords | DDS / ウイルス / ナノキャリア / ナノバイオ / ナノ粒子 / 生物工学 / 薬物輸送 / 薬物送達 / 薬物送達システム / バイオナノカプセル |
Outline of Final Research Achievements |
Through the analysis of hepatitis B virus envelope protein, we have identified the following novel functional domains: active targeting domain, stealth domain, and cell invasion domain. By displaying these domains as synthetic peptide, the artificial and conventional DDS carriers could function as next-gen DDS carrier that functions like hepatitis B virus. Furthermore, in other viruses, we have identified similar functional domains in their envelope proteins. These results strongly suggested that various next-gen DDS carriers could be generated by this strategy.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Mutational analysis of hepatitis B virus pre-S1 (9-24) fusogenic peptide.2016
Author(s)
Liu Q, Somiya M, Shimada N, Sakamoto W, Yoshimoto N, Iijima M, Tatematsu K, Nakai T, Okajima T, Maruyama A, and Kuroda S.
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Journal Title
Biochem. Biophys, Res. Commun.
Volume: 474
Pages: 406-412
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Cellular uptake of hepatitis B virus envelope L particles is independent of sodium taurocholate cotransporting polypeptide, but dependent on heparan sulfate proteoglycan.2016
Author(s)
Somiya M, Liu Q, Yoshimoto N, Iijima M, Tatematsu K, Nakai T, Okajima T, Kuroki K, Ueda K, and Kuroda S.
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Journal Title
Virology
Volume: 497
Pages: 23-32
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glyco-therapy2016
Author(s)
Takamatsu S, Shimomura M, Kamada Y, Maeda H, Sobajima T, Hikita H, Iijima M, Okamoto Y, Misaki R, Fujiyama K, Nagamori S, Kanai Y, Takehara T, Ueda K, Kuroda S, and Miyoshi E.
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Journal Title
Glycobiology
Volume: 26
Pages: 1180-1189
Related Report
Peer Reviewed
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[Journal Article] Virosomes of hepatitis B virus envelope L proteins containing doxorubicin: synergistic enhancement of human liver-specific antitumor growth activity by radiotherapy.2015
Author(s)
Liu Q, Jung J, Somiya M, Iijima M, Yoshimoto N, Niimi T, Maturana AD, Shin SH, Jeong SY, Choi EK, and Kuroda S.
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Journal Title
Int J Nanomed.
Volume: 10
Pages: 4159-4172
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading2014
Author(s)
Nakamura, Y., Hasebe, A., Takahashi, K., Iijima, M., Yoshimoto, N., Maturana, A. D., Ting, K., Kuroda, S., and Niimi T.
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Journal Title
Journal of Biological Chemistry
Volume: 289
Issue: 14
Pages: 9781-9794
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA2014
Author(s)
Ohno M, Otsuka M, Kishikawa T, Shibata C, Yoshikawa T, Takata A, Muroyama R, Kowatari N, Sato M, Kato N, Kuroda S, and Koike K.
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Journal Title
Oncotarget
Volume: 5
Pages: 5581-5590
Related Report
Peer Reviewed
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[Journal Article] A cisplatin‑incorporated liposome that targets the epidermal growth factor receptor enhances radiotherapeutic efficacy without nephrotoxicity2014
Author(s)
Jung J, Jeong SY, Park SS, Shin SH, Ju EJ, Choi J, Park J, Lee JH, Kim I, Suh YA, Hwang JJ,
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Journal Title
Int J Oncology
Volume: 46
Issue: 3
Pages: 1268-1274
DOI
Related Report
Peer Reviewed
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[Journal Article] An automated system for high-throughput single cell-based breeding2013
Author(s)
Nobuo Yoshimoto, Akiko Kida, Xu Jie, Masaya Kurokawa, Masumi Iijima, Tomoaki Niimi, Andrés D. Maturana, Itoshi Nikaido, Hiroki R. Ueda, Kenji Tatematsu, Katsuyuki Tanizawa, Akihiko Kondo, Ikuo Fujii, Shun'ichi Kuroda
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Journal Title
Scientific Reports
Volume: 3
Issue: 1
Pages: 1191-1191
DOI
Related Report
Peer Reviewed / Open Access
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