| Co-Investigator(Kenkyū-buntansha) |
伊藤 明良 京都大学, 医学研究科, 助教 (50762134)
秋山 治彦 岐阜大学, 大学院医学系研究科, 教授 (60402830)
青山 朋樹 京都大学, 医学研究科, 准教授 (90378886)
長井 桃子 京都大学, 医学研究科, 研究員 (50755676)
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| Budget Amount *help |
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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| Outline of Final Research Achievements |
Purpose of the study was to verify the effect of culture temperature on chondrocyte and extracellular matrix, the effect of application of low-intensity pulsed ultrasound (LIPUS) after mesenchymal stromal cell (MSC) transplantation on regeneration of articular cartilage and subchondral bone, and the effect of treadmill walking (TW) on knee osteoarthritis. The 37 centigrade was effective to generate extracellular matrix, LIPUS was effective after MSC transplantation, and TW increased the expression of Bone Morphogenetic Proteins and prevented the progression of knee OA.
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