| Co-Investigator(Kenkyū-buntansha) |
梅川 雄一 大阪大学, 理学(系)研究科(研究院), 助教 (20587779)
土川 博史 大阪大学, 理学(系)研究科(研究院), 助教 (30460992)
松森 信明 九州大学, 理学(系)研究科(研究院), 教授 (50314357)
花島 慎弥 大阪大学, 理学(系)研究科(研究院), 講師 (50373353)
松岡 茂 大阪大学, 理学(系)研究科(研究院), 准教授 (60456184)
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| Budget Amount *help |
¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2016: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2014: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2013: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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| Outline of Final Research Achievements |
In this research, we first explored natural products that alter the signal transduction in biological membranes by binding to lipid rafts. At the same time, these lipid-specific molecular probes help to extend the area of the chemical biology to lipid membrane area. During the research period, we were able to achieve the initial goals as already published in 26 scientific papers. For example, cyclic peptides, theonellamides, which was known to bind to sterols in joint research, was revealed to interact with membrane sterol in a different way from other sterol-associating compounds like saponins. Remarkable progress of sterol recognition mechanism have been obtained by the mechanism-of-action studies on amphidinol 3 and amphotericin B.
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