| Co-Investigator(Renkei-kenkyūsha) |
TAKAO Keizo 生理学研究所, 行動代謝分子解析センター, 特任准教授 (80420397)
Ohira Koji 藤田保健衛生大学, 総合医科学研究所, 講師 (80402832)
Hagihara Hideo 藤田保健衛生大学, 総合医科学研究所, 助教 (80514504)
Koshimizu Hisatsugu 藤田保健衛生大学, 総合医科学研究所, 助教 (10610842)
UMEMORI Juzoh 藤田保健衛生大学, 総合医科学研究所, 助教 (20462913)
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| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2016: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Previously we identified the “immature dentate gyrus (iDG),” a brain endophenotype shared in animal models of several psychiatric disorder, including schizophrenia and bipolar disorder. In this study, we sought to elucidate the mechanism of bi-directional changes in neuronal maturation status, and to develop the method for manipulation of maturation status, by using various cutting-edge technologies. We identified gene sets potentially involved in the development of iDG, by informatics analysis. Using optogenetics, we detected the condition under which temporal de-maturation status alters to permanent de-maturation status.
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