| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2016: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2015: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2014: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2013: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
|
|---|
| Outline of Final Research Achievements |
This project was focused on the developments and applications of catalytic alkylation reactions. The significant achievements are as follows. Alkyl-alkyl cross-coupling reactions using Fe, Co, Ni, and Cu along with unsaturated hydrocarbon additives were developed and examined in detail. The Cu catalyst shows quite high catalytic activity, achieving more than 1 million TON. The Co catalyst enables cross-coupling of tertiary alkyl Grignard regents to construct quaternary carbon centers. Site-selective alkylation of 1,3-dienes at the internal carbon was achieved by Cu catalyst. Ni catalyst enables multicomponent coupling reactions of 1,3-butadiene. We succeeded in isolation of anionic Ni complexes, that have been proposed as the key catalytic intermediates in the cross-coupling reactions.
Natural products containing a long alkyl chain were synthesized using Ni-catalysts. Another achievement includes development of chemical transformations of less reactive bonds such as C-F, C-O and C-H.
|
