Development of new transformations based on transition metal-catalyzed alkylation and its applications
| Project/Area Number |
25248025
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Kambe Nobuaki 大阪大学, 工学研究科, 教授 (60144432)
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| Project Period (FY) |
2013-05-31 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2016: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2015: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2014: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2013: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Keywords | クロスカップリング反応 / 多成分反応 / アルキル化反応 / 遷移金属触媒 / コバルト |
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| Outline of Final Research Achievements |
This project was focused on the developments and applications of catalytic alkylation reactions. The significant achievements are as follows. Alkyl-alkyl cross-coupling reactions using Fe, Co, Ni, and Cu along with unsaturated hydrocarbon additives were developed and examined in detail. The Cu catalyst shows quite high catalytic activity, achieving more than 1 million TON. The Co catalyst enables cross-coupling of tertiary alkyl Grignard regents to construct quaternary carbon centers. Site-selective alkylation of 1,3-dienes at the internal carbon was achieved by Cu catalyst. Ni catalyst enables multicomponent coupling reactions of 1,3-butadiene. We succeeded in isolation of anionic Ni complexes, that have been proposed as the key catalytic intermediates in the cross-coupling reactions.
Natural products containing a long alkyl chain were synthesized using Ni-catalysts. Another achievement includes development of chemical transformations of less reactive bonds such as C-F, C-O and C-H.
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Report
(5 results)
Research Products
(107 results)
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[Journal Article] Regioselective phosphorylation of myo-inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol2016
Author(s)
Aiba, T., Sato, M., Umegaki, D., Iwasaki, T., Kambe, N., Fukase, K., Fujimoto, Y.
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Journal Title
Organic & Biomolecular Chemistry
Volume: 14
Pages: 6672-6675
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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