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Development of optogenetics visual servo microscope

Research Project

Project/Area Number 25249020
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Dynamics/Control
Research InstitutionTohoku University

Principal Investigator

Hashimoto Koichi  東北大学, 情報科学研究科, 教授 (80228410)

Co-Investigator(Kenkyū-buntansha) 木村 幸太郎  大阪大学, 理学(系)研究科(研究院), 准教授 (20370116)
Co-Investigator(Renkei-kenkyūsha) HIGASHITANI ATSUSHI  東北大学, 大学院生命科学研究科, 教授 (40212162)
KAGAMI SHINGO  東北大学, 大学院情報科学研究科, 准教授 (90361542)
ARAI SHOGO  東北大学, 大学院工学研究科, 准教授 (80587874)
Project Period (FY) 2013-05-31 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2014: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2013: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Keywordsビジュアルサーボ / プロジェクションマッピング / オプトジェネティクス / 神経科学 / ロボット顕微鏡 / システム工学 / プロジェクタ / 分子遺伝学 / トラッキング / 制御機器 / 神経活動解析
Outline of Final Research Achievements

In this study, in order to analyze the brain function mainly by the sensory response behavior system, we simultaneously stimulated neuronal activities, developed an external stimulus according to the state, and developed a system to measure behavior.
In particular, as the integration platform, we developed the world's first robot microscope "OSACaBeN" that automatically tracks moving observation objects at high speed to stimulate specific nerve cells by projection mapping, and the properties of multiple dopamine cells in nematodes during action are different from each other. Furthermore, regarding the smell response behavior of nematodes, we clarified the possibility of possessing brain functions common to humans and others, performing time-integrated information "decision making".

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (23 results)

All 2017 2016 2015 2013 Other

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Multiple Drosophila Tracking System with Heading Direction2017

    • Author(s)
      Pudith Sirigrivatanawong, Shogo Arai, Vladimiros Thoma and Koichi Hashimoto
    • Journal Title

      Sensors

      Volume: 17 Issue: 1 Pages: 96-96

    • DOI

      10.3390/s17010096

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Feedback Projection for 3D Measurements Under Complex Lighting Conditions2017

    • Author(s)
      Naoya Chiba, Shogo Arai, Koichi Hashimoto
    • Journal Title

      Proc. American Control Conference (ACC2017)

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional dissociation in sweet taste receptor neurons between and within taste or- gans of Drosophila.2016

    • Author(s)
      Thoma V, Knapek S, Arai S, Hartl M, Kohsaka H, Sirigrivatanawong P, Abe A, Hashimoto K, Tanimoto H.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 10678-10678

    • DOI

      10.1038/ncomms10678

    • Related Report
      2016 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In actio optophysiological analyses reveal functional diversification of dopaminergic neurons in the nematode C. elegans2016

    • Author(s)
      Tanimoto, Yuki, Zheng, Ying Grace, Fei, Xianfeng, Fujie, Yukako, Hashimoto, Koichi and Kimura, Koutarou D.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1

    • DOI

      10.1038/srep26297

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Model-Based Virtual Visual Servoing with Point Cloud Data2016

    • Author(s)
      Cherdsak Kingkan, Shogo Ito, Shogo Arai, Takashi Nammoto and Koichi Hashimoto
    • Journal Title

      Proc. Int. Conf. Intelligent Robots and Systems (IROS2016)

      Volume: - Pages: 5549-5555

    • DOI

      10.1109/iros.2016.7759816

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Display tracking using blended images with unknown mixing ratio as a template2016

    • Author(s)
      Akifumi Goto, Shingo Kagami, and Koichi Hashimoto
    • Journal Title

      Proc. 9th ACM SIGGRAPH Conference and Exhibition on Computer Graphics and Interactive Techniques in Asia (SIGGRAPH Asia 2016 Technical Briefs)

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of different behavioral components by neuropeptide and dopamine signalings in non-associative odor learning of Caenorhabditis elegans.2015

    • Author(s)
      Yamazoe-Umemoto, A.;Fujita, K.;Iino, Y.;Iwasaki, Y.;Kimura, K. D.
    • Journal Title

      Neurosci Res

      Volume: 99 Pages: 22-33

    • DOI

      10.1016/j.neures.2015.05.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different roles for different modulators in the learning of worms2015

    • Author(s)
      Kimura, K.D.
    • Journal Title

      Neurotransmitter

      Volume: 2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feedback regulation of microscopes by image processing.2013

    • Author(s)
      Tsukada, Y., Hashimoto, K.
    • Journal Title

      Develop Growth Differ.

      Volume: 55 Issue: 4 Pages: 550-562

    • DOI

      10.1111/dgd.12056

    • NAID

      40019735215

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Principal component analysis of odor coding at the level of third-order olfactory neurons in Drosophila.2013

    • Author(s)
      Hiroi M, Ohkura M, Nakai J, Matsuda N, Hashimoto K, Inoue K, Fiala A, *Tabata T
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 12 Pages: 1070-1081

    • DOI

      10.1111/gtc.12094

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frame Synchronization of High-Speed Vision Sensors with Respect to Temporally Encoded Illumination in Highly Dynamic Environments2013

    • Author(s)
      Lei Hou, Shingo Kagami, Koichi Hashimoto
    • Journal Title

      Sensors

      Volume: Vol. 13, No. 4 Issue: 4 Pages: 4102-4121

    • DOI

      10.3390/s130404102

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synchronization-free single-shot detection of imperceptible AR markers in a high-speed video display2016

    • Author(s)
      Tsutomu Kusanagi, Shingo Kagami and Koichi Hashimoto
    • Organizer
      Proc. 3rd International Workshop on Image Sensors and Imaging Systems (IWISS2016)
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Visual Servo Microscope for Estimating Koichi Hashimoto Brain Function2015

    • Author(s)
      Koichi Hashimoto
    • Organizer
      Workshop on Advances in Robotics
    • Place of Presentation
      Macau, China
    • Year and Date
      2015-12-04
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sticky projection mapping: 450-fps tracking projection onto a moving planar surface2015

    • Author(s)
      Shingo Kagami and Koichi Hashimoto
    • Organizer
      SIGGRAPH Asia 2015 Emerging Technologies
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-11-02
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Photo Billboarding: A Simple Method to Provide Clues that Relate Camera Views and a 2D Map for Mobile Pedestrian Navigation2015

    • Author(s)
      Junta Watanabe, Shingo Kagami and Koichi Hashimoto
    • Organizer
      Mixed and Augmented Reality (ISMAR), 2015 IEEE International Symposium on
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2015-09-29
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visual Servo Microscope for Optogenetic Manipulation and Neural Network Identification2015

    • Author(s)
      Koichi Hashimoto
    • Organizer
      International Conference of Mechatronic Applications
    • Place of Presentation
      Beijing, China
    • Year and Date
      2015-08-04
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Computations and molecular basis for exploratory navigation of the nematode C. elegans2015

    • Author(s)
      Kimura, K., Nakai, J., Hashimoto, K.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Machine Vision and Robotics in Brain Science2015

    • Author(s)
      Koichi Hashimoto
    • Organizer
      Frontiers of Brain Science
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-07-24
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiple Drosophila tracking and posture estimation algorithm2015

    • Author(s)
      Shogo Arai, Pudith Sirigrivatanawong and Koichi Hashimoto
    • Organizer
      Informatics, Electronics & Vision (ICIEV), 2015 International Conference on
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2015-06-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A neuronal algorithm for navigation along a repulsive odor gradient in the nematode C. elegans

    • Author(s)
      Kotaro Kimura
    • Organizer
      Center for Functional Connectomics
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] ロボット制御学ハンドブック、第9章、ビジュアルサーボ2016

    • Author(s)
      橋本浩一
    • Total Pages
      200
    • Publisher
      近代科学社
    • Related Report
      2015 Annual Research Report
  • [Book] Optogenetics―From neural function to mapping & disease biology2015

    • Author(s)
      Kimura, K.D., Busch, K.E.
    • Total Pages
      150
    • Publisher
      Cambridge University Press
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 画像処理装置2016

    • Inventor(s)
      橋本浩一、荒井翔悟、伊藤翔吾、キンカンチュアサク
    • Industrial Property Rights Holder
      橋本浩一、荒井翔悟、伊藤翔吾、キンカンチュアサク
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-22
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2013-06-20   Modified: 2019-07-29  

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