Search for marine natural products that inhibit the pathway from metabolic syndrome to cadiovascular diseases

• Project/Area Number: 25252037
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Aquatic life science
• Research Institution: The University of Tokyo
• Principal Investigator: Matsunaga Shigeki 東京大学, 大学院農学生命科学研究科(農学部), 教授 (60183951)
• Co-Investigator(Kenkyū-buntansha): 及川 勉 神奈川県立保健福祉大学, 保健福祉学部, 名誉教授 (40120141)
• Co-Investigator(Renkei-kenkyūsha): IKEDA Megumi 神奈川県立保健福祉大学, 保健福祉学部, 助手 (90535402)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000); Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2013: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
• Keywords: 脂肪細胞 / 分化誘導 / 海洋生物 / カイメン / 前駆脂肪細胞 / マクロファージ / 脂肪滴 / 生活習慣病 / 予防 / 海洋天然物 / フトツノザメ / 構造決定 / 生理活性物質

Outline of Final Research Achievements

When appropriately differentiated, adipocytes secret proteins that can prevent metabolic syndromes. Therefore, compounds that promote the differentiation of preadipocytes to adipocytes are expected to improve the status of geriatric diseases. After searching for compounds with such activities, we found many active compounds from the marine sponge Xestspongia testudinaria and determined their structures. From other sponges we isolated a theonellamide related compound and an aromatic alkaloid as the active principles.

Research Products

• [Journal Article] Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge (2016)
  • Author(s): Hitora, H.; Takada, K.; Ise, Y.; Okada, S.; Matsunaga, S.
  • Journal Title: Journal of Natural Products Volume: 79 Issue: 11 Pages: 2973-2976
  • DOI: 10.1021/acs.jnatprod.6b00710
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Curacin E from the Brittle Star Ophiocoma scolopendrina (2016)
  • Author(s): Ueoka, R.; Hitora, U.; Ito, A.; Yoshida, M.; Okada, S.; Takada, K.; Matsunaga, S.
  • Journal Title: Journal of Natural Products Volume: 79 Issue: 10 Pages: 2754-2757
  • DOI: 10.1021/acs.jnatprod.6b00701
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stimulators of adiponenesis from the marine sponge Xestospongia testudinaria (2013)
  • Author(s): Akiyama, T.; Takada, K.; Oikawa, T.; Matsuura, N.; Ise, Y.; Okada, S.; Matsunaga, S.
  • Journal Title: Tetrahedron Volume: 69 Issue: 32 Pages: 6560-6564
  • DOI: 10.1016/j.tet.2013.06.007
  • Peer Reviewed