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A Comprehensive Approach Encompassing New Therapeutics for Microsatellite-instability Associated Colorectal Neoplasms

Research Project

Project/Area Number 25253080
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Watanabe Toshiaki  東京大学, 医学部附属病院, 教授 (80210920)

Co-Investigator(Kenkyū-buntansha) Sato Toshiro  慶應義塾大学, 医学部, 准教授 (70365245)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2014: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2013: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Keywords大腸癌 / マイクロサテライト不安定性 / オルガノイド / DNAメチル化 / 鋸歯状腺腫 / 次世代シーケンス / マイクロアレイ / 発癌 / 幹細胞 / 遺伝子導入 / メチル化 / 大腸鋸歯状腺腫 / 大腸幹細胞 / エピジェネティクス
Outline of Final Research Achievements

We generated 55 organoid lines from colorectal neoplasms, including serrated lesions and MSI colon cancers, and elaborated their biological properties. The organoids pathophysiologically recapitulated the patient tumors and exhibited unique gene expression and genetic mutation patterns. MSI colon cancers harbored substantial number of non-synonymous mutations, allowing their robust growth in hostile conditions with poor growth factors. Similar property of the MSI colon cancer organodis was observed in the xenograft models, in which the MSI colon cancer organoids displayed significantly higher tumorigenic capacity. These data suggested that the MSI colorectal cancers distinctively differ from the other sporadic colorectal cancers in molecular and biological characters, highlighting the significance of the individual therapeutics toward eradication of the MSI colorectal cancers.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report

Research Products

(50 results)

All 2016 2015 2014 2013

All Journal Article

  • [Journal Article] A Colorectal Tumor Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis2016

    • Author(s)
      Fujii M, Shimokawa M, Date S, Takano A, Matano M, Nanki K, Ohta Y, Toshimitsu K, Nakazato Y, Kawasaki K, Uraoka T, Watanabe T, Kanai T, Sato T
    • Journal Title

      Cell Stem Cell

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy.2016

    • Author(s)
      Nozawa H, Ishihara S, Fujishiro M, Kodashima S, Ohtani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Surgery.

      Volume: 159 Pages: 713-20

    • DOI

      10.1016/j.surg.2015.09.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Surveillanace colonoscopy for colitis associated dysplasia and cancer in ulcerative colitis patients.2016

    • Author(s)
      Hata K, Kishikawa J, Anzai H, Shinagawa T, Kazama S, Ishii H, Nozawa H, Kawai K, Kiyomatsu T, Tanaka J, Tanaka T, Nishikawa T, Otani K, Yasuda K, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Digestive Endoscopy

      Volume: 28 Pages: 260-265

    • DOI

      10.1111/den.12505

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficient genetic engineering of human intestinal organoids using electroporation.2015

    • Author(s)
      Fujii M, Matano M, Nanki K, Sato T.
    • Journal Title

      Nat Protoc.

      Volume: 10 Pages: 1474-85

    • DOI

      10.1038/nprot.2015.088

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modeling colorectal cancer using CRISPR-Cas9– mediated engineering of human intestinal organoids2015

    • Author(s)
      Matano M,Date S, Shimokawa M, Takano A, Fujii M, Ohta Y, Watanabe T, Kanai T, Sato T.
    • Journal Title

      Nat Med

      Volume: 21(3) Pages: 256-262

    • DOI

      10.1038/nm.3802

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer.2015

    • Author(s)
      Watanabe T, Itabashi M, Shimada Y, Sugihara K
    • Journal Title

      Int J Clin Oncol

      Volume: 20(2) Pages: 207-239

    • DOI

      10.1007/s10147-015-0801-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Benefit of primary tumor resection in stage IV colorectal cancer with unresectable metastasis: a multicenter retrospective study using a propensity score analysis.2015

    • Author(s)
      Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Sugihara K, Watanabe T.
    • Journal Title

      Int J Colorectal Dis.

      Volume: 30 Pages: 807-12

    • DOI

      10.1007/s00384-015-2228-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer.2015

    • Author(s)
      Kazama S, Kitayama J, Hiyoshi M, Taketomi Y, Murakami M, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Yamaguchi H, Nozawa H, Ishihara S, Sunami E, Watanabe T.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 2983-90

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Initial safety report on the tolerability of modified FOLFOX6 as adjuvant therapy in patients with curatively resected stage II or III colon cancer (JFMC41-1001-C2: JOIN trial).2015

    • Author(s)
      Kotaka M, Yoshino T, Oba K, Shinozaki K, Touyama T, Manaka D, Matsui T, Ishigure K, Hasegawa J, Inoue K, Goto K, Sakamoto J, Saji S, Ohtsu A, Watanabe T.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 76 Pages: 75-84

    • DOI

      10.1007/s00280-015-2757-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients.2015

    • Author(s)
      Nagai Y, Yamamoto Y, Yasuhara T, Hata K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Yamanaka T, Miyagawa K, Watanabe T.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 21064-73

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prognostic Impact of Histologic Type in Curatively Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective Study.2015

    • Author(s)
      Shibata J, Kawai K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Sugihara K, Watanabe T.
    • Journal Title

      Ann Surg Oncol

      Volume: Suppl 3

    • DOI

      10.1245/s10434-015-4846-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] CD133 Expression in Lymph Node Metastases Is Associated with Tumor Aggressiveness During Lymph Node Metastasis in Colorectal Cancer.2015

    • Author(s)
      Kazama S, Kishikawa J, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Watanabe T.
    • Journal Title

      Anticancer Res

      Volume: 35 Pages: 6599-605

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Predictors and outcome of complete removal of colorectal cancer with synchronous lung metastases.2015

    • Author(s)
      Nozawa H, Tanaka J, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Nakajima J, Kokudo N, Watanabe T.
    • Journal Title

      Mol Clin Oncol

      Volume: 3 Pages: 1041-1047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (SHOGUN trial).2015

    • Author(s)
      Matsusaka S, Ishihara S, Kondo K, Horie H, Uehara K, Oguchi M, Murofushi K, Ueno M, Mizunuma N, Shimbo T, Kato D, Okuda J, Hashiguchi Y, Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada T, Ishikawa Y, Nakajima T, Watanabe T.
    • Journal Title

      Radiother Oncol

      Volume: 116 Pages: 209-13

    • DOI

      10.1016/j.radonc.2015.08.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recent advances in robotic surgery for rectal cancer.2015

    • Author(s)
      Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka J, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Int J Clin Oncol

      Volume: 20 Pages: 633-40

    • DOI

      10.1007/s10147-015-0854-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer.2015

    • Author(s)
      Ozawa T, Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Int J Colorectal Dis

      Volume: 30 Pages: 1165-71

    • DOI

      10.1007/s00384-015-2276-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Analysis of anastomotic leakage after rectal surgery: A case-control study.2015

    • Author(s)
      Tanaka J, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Kazama S, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Ann Med Surg

      Volume: 11 Pages: 183-6

    • DOI

      10.1016/j.amsu.2015.05.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prediction of the preoperative chemoradiotherapy response for rectal cancer by peripheral blood lymphocyte subsets.2015

    • Author(s)
      Tada N, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Oba K, Watanabe T.
    • Journal Title

      World J Surg Oncol

      Volume: 13 Pages: 30-30

    • DOI

      10.1186/s12957-014-0418-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.2015

    • Author(s)
      Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1459-64

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Log odds of positive lymph nodes as a prognostic indicator in stage IV colorectal cancer patients undergoing curative resection.2015

    • Author(s)
      Ozawa T, Ishihara S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      J Surg Oncol

      Volume: 111 Pages: 465-71

    • DOI

      10.1002/jso.23855

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial).2015

    • Author(s)
      Ishihara S, Matsusaka S, Kondo K, Horie H, Uehara K, Oguchi M, Murofushi K, Ueno M, Mizunuma N, Shinbo T, Kato D, Okuda J, Hashiguchi Y, Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada T, Ishikawa Y, Nakajima T, Watanabe T.
    • Journal Title

      Radiat Oncol

      Volume: 10 Pages: 24-24

    • DOI

      10.1186/s13014-015-0333-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection.2015

    • Author(s)
      Ozawa T, Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Ann Surg Oncol

      Volume: 22 Pages: 1513-9

    • DOI

      10.1245/s10434-014-4184-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nomogram prediction of metachronous colorectal neoplasms in patients with colorectal cancer.2015

    • Author(s)
      Kawai K, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Miyata H, Watanabe T.
    • Journal Title

      Ann Surg

      Volume: 261 Pages: 926-32

    • DOI

      10.1097/sla.0000000000000881

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of carcinoembryonic antigen mRNA in peritoneal lavage by the transcription-reverse transcription concerted method indicates poor prognosis in patients with stage II and III colon cancer.2015

    • Author(s)
      Murono K, Kazama S, Yamaguchi H, Kawai K, Ishihara S, Sunami E, Kitayama J, Satoh Y, Kurihara M, Yatomi Y, Watanabe T.
    • Journal Title

      Surgery.

      Volume: 157 Pages: 322-30

    • DOI

      10.1016/j.surg.2014.09.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and prognostic significance of positive peritoneal lavage in colorectal cancer.2015

    • Author(s)
      Nishikawa T, Sunami E, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S, Nozawa H, Ishihara S, Watanabe T.
    • Journal Title

      Surg Today

      Volume: Epub ahead of print

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics and prognosis of colorectal cancer associated with rheumatic disease.2015

    • Author(s)
      Kishikawa J, Kawai K, Tsuno N, Yamaguchi H, Ishihara S, Sunami E, Watanabe T.
    • Journal Title

      Int Surg

      Volume: Epub ahead of print

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of primary tumor resection and lymph node dissection in stage IV colorectal cancer with unresectable metastasis: a propensity score analysis in a multicenter retrospective study.2014

    • Author(s)
      Ishihara S, Hayama T, Yamada H, Nozawa K, Matsuda K, Miyata H, Yoneyama S, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y, Sugihara K, Watanabe T.
    • Journal Title

      Ann Surg Oncol.

      Volume: 21 Pages: 2949-55

    • DOI

      10.1245/s10434-014-3719-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear Notch3 Expression is Associated with Tumor Recurrence in Patients with Stage II and III Colorectal Cancer2014

    • Author(s)
      Ozawa T, Kazama S, Akiyoshi T, Murono K, Yoneyama S, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kanazawa T, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Morikawa T, Fukayama M, Watanabe T.
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Pages: 2650-8

    • DOI

      10.1245/s10434-014-3659-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of response to preoperative chemoradiotherapy in rectal cancer by using reverse transcriptase polymerase chain reaction analysis of four genes2014

    • Author(s)
      Watanabe T, Kobunai T, Akiyoshi T, Matsuda K, Ishihara S, Nozawa K.
    • Journal Title

      Dis Colon Rectum

      Volume: 57(1) Pages: 23-31

    • DOI

      10.1097/01.dcr.0000437688.33795.9d

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients.2014

    • Author(s)
      Tada N, Tsuno NH, Kawai K, Murono K, Nirei T, Ishihara S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Oncol Rep.

      Volume: 31 Pages: 463-71

    • DOI

      10.3892/or.2013.2857

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells.2014

    • Author(s)
      Nakaya T, Ogawa S, Manabe I, Tanaka M, Sanada M, Sato T, Taketo MM, Nakao K, Clevers H, Fukayama M, Kuroda M, Nagai R.
    • Journal Title

      Cancer Res

      Volume: Epub ahead of print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation2014

    • Author(s)
      Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T.
    • Journal Title

      PLoS One.

      Volume: 9 Pages: 1-1

    • DOI

      10.1371/journal.pone.0084619

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis.2014

    • Author(s)
      Kobayashi H, Kotake K, Funahashi K, Hase K, Hirata K, Iiai T, Kameoka S, Kanemitsu Y, Maeda K, Murata A, Ohue M, Shirouzu K, Takahashi K, Watanabe T, Yano H, Yatsuoka T, Hashiguchi Y, Sugihara K
    • Journal Title

      J Gastroenterology

      Volume: 49(4) Pages: 646-54

    • DOI

      10.1007/s00535-013-0820-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salvage Gastrectomy After Intravenous and Intraperitoneal Paclitaxel (PTX) Administration with Oral S-1 for Peritoneal Dissemination of Advanced Gastric Cancer with Malignant Ascites.2014

    • Author(s)
      Kitayama J, Ishigami H, Yamaguchi H, Yamashita H, Emoto S, Kaisaki S, Watanabe T.
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Pages: 539-46

    • DOI

      10.1245/s10434-013-3208-y

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD90(+) mesothelial-like cells in peritoneal fluid promote peritoneal metastasis by forming a tumor permissive microenvironment.2014

    • Author(s)
      Kitayama J
    • Journal Title

      PloS One

      Volume: 21;9(1)

    • DOI

      10.1371/journal.pone.0086516

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Flow cytometric quantification of intraperitoneal free tumor cells (FTC) in patients with peritoneal metastasis.2014

    • Author(s)
      Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Kamei T, Yamashita H, Seto Y, Matsuzaki K, Watanabe T.
    • Journal Title

      Cytometry B Clin Cytom.

      Volume: 86 Pages: 56-62

    • DOI

      10.1002/cyto.b.21126

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Colorectal cancer and hypercoagulability.2014

    • Author(s)
      Kawai K, Watanabe T.
    • Journal Title

      Surg Today

      Volume: 44(5) Pages: 797-803

    • DOI

      10.1007/s00595-013-0606-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer.2014

    • Author(s)
      Kawai K.
    • Journal Title

      Int J Colorectal Dis

      Volume: 28(4):527 Pages: 527-35

    • DOI

      10.1007/s00384-012-1594-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraperitoneal administration of cisplatin via an in situ cross-linkable hyaluronic acid-based hydrogel for peritoneal dissemination of gastric cancer2014

    • Author(s)
      Emoto S, Yamaguchi H, Kamei T, Ishigami H, Suhara T, Suzuki Y, Ito T, Kitayama J, Watanabe T.
    • Journal Title

      Sugery Today

      Volume: 44 Pages: 919-26

    • DOI

      10.1007/s00595-013-0674-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selective lateral pelvic lymph node dissection in patients with advanced low rectal cancer treated with preoperative chemoradiotherapy based on the pretreatment imaging2014

    • Author(s)
      Akiyoshi T, Ueno M, Matsueda K, Konishi T, Fujimoto Y, Nagayama S, Fukunaga Y, Unno T, Kano A, Kuroyanagi H, Oya M, Yamaguchi T, Watanabe T, Muto T.
    • Journal Title

      Ann Surg Oncol

      Volume: 21(1) Pages: 189-196

    • DOI

      10.1245/s10434-013-3216-y

    • NAID

      40020186230

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and factors contributing to the difficulty of laparoscopic surgery for rectal cancer treated with preoperative chemoradiotherapy.2014

    • Author(s)
      Ishihara S, Watanabe T, Fukushima Y, Akahane T, Horiuchi A, Shimada R, Nakamura K, Hayama T, Yamada H, Nozawa K, Matsuda K, Hashiguchi Y.
    • Journal Title

      Tech Coloproctol

      Volume: 18(3) Pages: 247-255

    • DOI

      10.1007/s10151-013-1048-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis2013

    • Author(s)
      Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H.
    • Journal Title

      EMBO J

      Volume: 32(20) Pages: 2708-21

    • DOI

      10.1038/emboj.2013.204

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.2013

    • Author(s)
      Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hlbi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T.
    • Journal Title

      Cell Host Microbe.

      Volume: 13 Pages: 711-22

    • DOI

      10.1016/j.chom.2013.05.013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growing self-organizing mini-guts from a single intestinal stem cell : mechanism and applications2013

    • Author(s)
      Sato T, Clevers H.
    • Journal Title

      Science

      Volume: 340(6137) Pages: 1190-4

    • DOI

      10.1126/science.1234852

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-22-producing RORγt-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis2013

    • Author(s)
      Matsumoto A, Kanai T, Mikami Y, Chu PS, Nakamoto N, Ebinuma H, Saito H, Sato T, Yagita H, Hibi T.
    • Journal Title

      PLoS One.

      Volume: 8

    • DOI

      10.1371/journal.pone.0062853

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.2013

    • Author(s)
      Huch M, Dorrell C, Boj SF, van Es JH, Li VSW, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries R, Grompe M, Clevers H.
    • Journal Title

      Nature

      Volume: 494(7436) Pages: 247-50

    • DOI

      10.1038/nature11826

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase 2 trial of intravenous and intraperitoneal paclitaxel combined with S-1 for treatment of gastric cancer with macroscopic peritoneal metastasis.2013

    • Author(s)
      Yamaguchi H, Kitayama J, Ishigami H, Emoto S, Yamashita H, Watanabe T.
    • Journal Title

      Cancer

      Volume: 119 Pages: 3354-8

    • DOI

      10.1002/cncr.28204

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KRAS Mutational Status in Japanese Patients with Colorectal Cancer: Results from a Nationwide, Multicenter, Cross-sectional Study.2013

    • Author(s)
      Watanabe T, Yoshino T, Uetake H, Yamazaki K, Ishiguro M, Kurokawa T, Saijo N, Ohashi Y, Sugihara K.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43(7) Pages: 706-12

    • DOI

      10.1093/jjco/hyt062

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer.2013

    • Author(s)
      Murono K, Kitayama J, Tsuno NH, Nozawa H, Kawai K, Sunami E, Akahane M, Watanabe T.
    • Journal Title

      Int J Colorectal Dis

      Volume: 28(8) Pages: 1065-1072

    • DOI

      10.1007/s00384-013-1656-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia enhances colon cancer migration and invasion through promotion of epithelial-mesenchymal transition.2013

    • Author(s)
      Hongo K, Tsuno NH, Kawai K, Sasaki K, Kaneko M, Hiyoshi M, Murono K, Tada N, Nirei T, Sunami E, Takahashi K, Nagawa H, Kitayama J, Watanabe T.
    • Journal Title

      J Surg Res

      Volume: 182(1) Pages: 75-84

    • DOI

      10.1016/j.jss.2012.08.034

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed

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Published: 2013-05-15   Modified: 2019-07-29  

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