| Co-Investigator(Kenkyū-buntansha) |
鄭 雄一 東京大学, 工学(系)研究科(研究院), 教授 (30345053)
筑田 博隆 東京大学, 医学部附属病院, 准教授 (30345219)
森崎 裕 東京大学, 医学部附属病院, 助教 (30508099)
岡 敬之 東京大学, 医学部附属病院, 助教 (60401064)
乾 洋 東京大学, 医学部附属病院, 助教 (60583119)
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| Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2013: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
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| Outline of Final Research Achievements |
We have investigated molecular mechanisms of osteoarthritis in this project, and we have identified that Notch and NF-kappaB signaling pathways play essential roles in osteoarthritis development. In Notch-related genes, Jag1-Notch-Hes1 pathway is most important, and inhibition of this pathway suppressed osteoarthritis. Complete inhibition of NF-kappaB caused chondrocyte apoptosis, and resulted in enhancement of osteoarthritis. In contrast, osteoarthritis was suppressed when NF-kappaB was inhibited partially, indicating that NF-kappaB regulation is essential for cartilage homeostasis.
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