Aromatase induces ovulation via a reduction of follicular androgen and its application for infertility treatment
| Project/Area Number |
25253092
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Chiba University |
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Principal Investigator |
SHOZU Makio 千葉大学, 大学院医学研究院, 教授 (30226302)
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| Co-Investigator(Kenkyū-buntansha) |
幡野 雅彦 千葉大学, 大学院医学研究院, 教授 (20208523)
石川 博士 千葉大学, 大学院医学研究院, 助教 (70553973)
花岡 英紀 千葉大学, 医学部附属病院, 教授 (80361426)
碓井 宏和 千葉大学, 大学院医学研究院, 講師 (90375634)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥38,870,000 (Direct Cost: ¥29,900,000、Indirect Cost: ¥8,970,000)
Fiscal Year 2015: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2014: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
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| Keywords | 生殖医学 / アロマターゼ / 産婦人科学 |
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| Outline of Final Research Achievements |
We tested the hypothesis that aromatase trigger follicular rupture (ovulation) via a reduction of local androgen levels and tried to develop new treatment based on the theory. We developed in vitro PCOS model in which low dose hCG causes ovulatory response low. In this model, Cyp17a1 inhibitor which restored ovulatory responses of the model as well as oocyte maturation. The human oocytes were recovered from small non-dominant follicles of infertile women who underwent IVF-ET therapy. At least one forth of these oocytes were metaphase II and competent for live birth. This indicates that al least a part of the non-dominant follicles maintains oocyte competency until mid-cycle ovulation despite the high androgen status. Needle aspiration of those follicle and following IVF-ET may be an alternate therapy for those anovulatory women without gonadotropins-induced ovulation.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Efficient Subtractive Cloning of Genes Activated by Lipopolysaccharide and Interferon γ in Primary-Cultured Cortical Cells of Newborn Mice2013
Author(s)
Miyauchi, O., Iwase, K., Itoh, K., Kato, M., Seki, N., Braissant, O., Bachmann, C., Shozu, M., Sekiya, S., Osada, H., and Takiguchi, M.
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Journal Title
DOI
Related Report
Peer Reviewed
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[Journal Article] Genomic Basis of Aromatase Excess Syndrome: Recombination-and Replication-Mediated Rearrangements Leading to CYP19A1 Overexpression.2013
Author(s)
Fukami M*, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Gurger H, Sompson ER, Emezawa A, Nakabayashi K, Bulun SE, Shozu M, Ogata T
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Journal Title
J Clin Ecdocrinol Metab
Volume: 98
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma.2013
Author(s)
Yamamoto N, Kinoshita T, Nohata N, Yoshino H, Itesako T, Fujimura L, Mitsuhashi A, Usui H, Enokida H, Nakagawa M, Shozu M, and Seki N
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Journal Title
Int J Oncol.
Volume: 43
Pages: 1855-1863
DOI
Related Report
Peer Reviewed
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[Presentation] Oocyte retrival from collateral follicles improves outcomes of natural or low ovarian stimulus cycle IVF2013
Author(s)
Segawa T, Teramoto S, Miyauchi O, Watanabe Y, Hayashi T, Ohkubo T, Onda N, Ueno T, Tsuchiyama S, Shinohara K, Yelian F, Ishikawa H, Shozu M
Organizer
European Society of Human Reproduction and Embryology Annual Meeting
Place of Presentation
London, U.K
Year and Date
2013-07-07 – 2013-07-10
Related Report
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