Study of hippocampal function with electrical activity in temporal cognition

• Project/Area Number: 25280051
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cognitive science
• Research Institution: Hiroshima University
• Principal Investigator: Sakata Shogo 広島大学, 総合科学研究科, 教授 (50153888)
• Co-Investigator(Kenkyū-buntansha): Ito Isao 九州大学, 理学研究院, 教授 (20183741) ; Okada Kana 広島大学, 大学院総合科学研究科, 特任助教 (50528263)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 時間認知 / 脳認知科学 / 時間情報処理 / 海馬機能 / 海馬の非対称性 / 海馬シータ波 / ピーク法

Outline of Final Research Achievements

Time is truly ubiquitous. Time is very important to living animals. This study focused on the hippocampal function in the temporal cognition and was going to clarify the relationship between brain region and their electrophysiological activity. Rats were trained using peak interval (PI) 30-s procedure that include empty probe trials using at response peak time and measured the hippocampal θ activity during PI task performance. It can calculate to evaluate as a power level by doing FFT analysis. We have measured as an objective evaluation of the hippocampal θ wave how it works. We sorted progress and the correspondency of the hippocampal θ wave in frequency band at peak time. Even mice were able to attract behavioral data by long-term training using the same PI procedure. There is the electroencephalographic comparison between the iv mouse which reversed the right and left components and C57BL/6J which is generally used by an experiment in the future study.

Research Products

• [Journal Article] ラットのピーク法を用いた計時行動のセッション間安定性の検討 (2015)
  • Author(s): 氏田麻美・服部稔・坂田省吾
  • Journal Title: 基礎心理学研究 Volume: 34 Pages: 17-26
  • NAID: 130005118247
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The transient decline in hippocampal theta power during response inhibition in a positive patterning task. (2015)
  • Author(s): Sakimoto, Y., *Sakata, S.
  • Journal Title: NeuroReport Volume: 26 Issue: 14 Pages: 833-837
  • DOI: 10.1097/wnr.0000000000000432
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Behavioral inhibition during a conflict state elicits a transient decline in hippocampal theta power. (2015)
  • Author(s): Sakimoto, Y., *Sakata, S.
  • Journal Title: Behavioural brain research Volume: 290 Pages: 70-76
  • DOI: 10.1016/j.bbr.2015.03.060
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Change in hippocampal theta activity during behavioral inhibition for a stimulus having an overlapping element. (2015)
  • Author(s): Sakimoto, Y., *Sakata, S.
  • Journal Title: Behavioural brain research Volume: 282 Pages: 111-116
  • DOI: 10.1016/j.bbr.2014.12.041
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory. (2015)
  • Author(s): Okada K, Nishizawa K, Kobayashi T, Sakata S, Kobayashi K.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 13158-13158
  • DOI: 10.1038/srep13158
  • Peer Reviewed / Open Access
• [Journal Article] 先行経験の違いがラットの衝動性の指標に及ぼす影響 (2015)
  • Author(s): 秋山芙美・新倉怜・坂田省吾
  • Journal Title: 人間科学研究 Volume: 10 Pages: 1-7
  • NAID: 120005712986
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A model of multisecond timing behaviour under peak-interval procedures. (2015)
  • Author(s): Hasegawa, T., Sakata, S.
  • Journal Title: Journal of Computational Neuroscience Volume: 38 Issue: 2 Pages: 301-313
  • DOI: 10.1007/s10827-014-0542-4
  • Peer Reviewed / Open Access
• [Journal Article] Hippocampal theta activity during behavioral inhibition for conflicting stimuli. (2014)
  • Author(s): Sakimoto, Y., *Sakata, S.
  • Journal Title: Behavioural brain research Volume: 275 Pages: 183-190
  • DOI: 10.1016/j.bbr.2014.08.063
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Change in hippocampal theta activity with transfer from simple discrimination tasks to a simultaneous feature-negative task. (2014)
  • Author(s): Sakimoto, Y., *Sakata, S.
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 8 Pages: 1-9
  • DOI: 10.3389/fnbeh.2014.00159
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhanced flexibility of place discrimination learning by targeting of striatal cholinergic interneurons. (2014)
  • Author(s): Okada, K., Nishizawa, K., Fukabori, R., Kai, N., Shiota, A., Ueda, S., Tsutsui, Y., Sakata, S., Matsushita, N., and Kobayashi, K.
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 3778-3778
  • DOI: 10.1038/ncomms4778
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes. (2014)
  • Author(s): Fujioka R, Nii T, Iwaki A, Shibata A, Ito I, Kitaichi K, Nomura M, Hattori S, Takao K, Miyakawa T, Fukumaki Y.
  • Journal Title: Mol Brain Volume: 7 Issue: 1 Pages: 31-31
  • DOI: 10.1186/1756-6606-7-31
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Retrospective and Prospective Views on the Role of the Hippocampus in Interval Timing and Memory for Elapsed Time. (2014)
  • Author(s): MacDonald, C.J., Fortin, N. J., Sakata, S. and Meck, W. H.
  • Journal Title: Timing & Time Perception Volume: 2 Issue: 1 Pages: 51-61
  • DOI: 10.1163/22134468-00002020
  • Peer Reviewed
• [Journal Article] Brain electrophysiological activity correlates with temporal processing in rats. (2014)
  • Author(s): Hattori, M. & Sakata, S.
  • Journal Title: Behavioural Processes Volume: 201 Pages: 97-102
  • DOI: 10.1016/j.beproc.2013.09.011
  • Peer Reviewed
• [Journal Article] Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry. (2013)
  • Author(s): A. Kawahara, S. Kurauchi, Y. Fukata, J. Hernandez, T. Yagihashi, Y. Itadani, R. Sho, T. Kajiyama, N. Shinzato, K. Narusuye, M. Fukata, R. Lujan, R. Shigemoto, I. Ito.
  • Journal Title: Journal of Psysiology Volume: 591 Pages: 4777-4791
  • NAID: 120005315161
  • Peer Reviewed
• [Presentation] The study of the shift of temporal bisection point in rats. (2016)
  • Author(s): Shogo Sakata
  • Organizer: 脳と心のメカニズム 第16回冬のワークショップ
  • Place of Presentation: 北海道ルスツリゾート
  • Year and Date: 2016-01-06
• [Presentation] Study of the interval timing with administration of NMDA antagonist in rats. (2015)
  • Author(s): Sakata, S., Ujita, A., & Hattori, M.
  • Organizer: Society for Neuroscience Annual Meeting, Neuroscience 2015
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Study of temporal expectations with peak-interval procedure in rats. (2015)
  • Author(s): Sakata, S., Ujita, A., & Hattori, M.
  • Organizer: International Symposium on the Science of Mental Time
  • Place of Presentation: 東京都東工大キャンパスイノベーションセンター
  • Year and Date: 2015-09-12
  • Int'l Joint Research
• [Presentation] The procedure of adjusted delay task in rats. (2015)
  • Author(s): Fumi Akiyama, Shogo Sakata
  • Organizer: 日本動物心理学会
  • Place of Presentation: 東京都日本女子大学
  • Year and Date: 2015-09-10
• [Presentation] Peak-interval procedure and the striatum EEG power in rats. (2015)
  • Author(s): Shogo Sakata, Yusuke Kino, Minoru Hattori
  • Organizer: The 38th annual meeting of the Japan Neuroscience Society
  • Place of Presentation: 兵庫県神戸国際会議場
  • Year and Date: 2015-07-28
• [Presentation] Administration of NMDA antagonist shifts the interval timing peak rightward in rats. (2015)
  • Author(s): Sakata, S., Ujita, A., Kino, K., Hattori, M.
  • Organizer: 日本生理学会
  • Place of Presentation: 神戸コンベンションセンター(神戸国際会議場・神戸国際展示場)
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] The study of learning criterion with temporal cognition task: peak interval procedure in rats. (2015)
  • Author(s): Shogo Sakata, Asami Ujita, Minoru Hattori
  • Organizer: 脳と心のメカニズム 第15回冬のワークショップ
  • Place of Presentation: ルスツリゾートホテル（北海道）
  • Year and Date: 2015-01-07 – 2015-01-08
• [Presentation] ペア型免疫グロブリン様受容体が神経回路の非対称性形成に関与する (2014)
  • Author(s): 鵜飼ひかり、愛野翔太郎、脇田健、宮部真裕、笠行通代、伊藤功
  • Organizer: 第６５回西日本生理学会
  • Place of Presentation: 琉球大学（沖縄）
  • Year and Date: 2014-10-23 – 2014-10-24
• [Presentation] Striatum EEG Power Correlates with Timing in rats. (2014)
  • Author(s): Minoru Hattori,Asami Ujita, Kana Okada, Shogo Sakata
  • Organizer: XVII Biennial Meeting of the International Society for Comparative Psychology
  • Place of Presentation: TRYP Hotel ( Bogota, Colombia )
  • Year and Date: 2014-09-10 – 2014-09-12
  • Invited
• [Presentation] Hippocampal Theta and Learning Behavior (2014)
  • Author(s): Sakata, S.
  • Organizer: XVII Biennial Meeting of the International Society for Comparative Psychology
  • Place of Presentation: TRYP Hotel ( Bogota, Colombia )
  • Year and Date: 2014-09-10 – 2014-09-12
  • Invited
• [Presentation] ラットにおける時間認知と脳活動. (2014)
  • Author(s): 坂田省吾
  • Organizer: 日本生理心理学会
  • Place of Presentation: 筑波大学大学会館（つくば市）
  • Year and Date: 2014-05-17 – 2014-05-18
  • Invited
• [Presentation] ラットにおける時間認知と脳活動 (2014)
  • Author(s): 坂田省吾
  • Organizer: 第32回日本生理心理学会大会
  • Place of Presentation: 筑波大学 大学会館
  • Invited
• [Presentation] Molecular asymmetries in the brain. (2013)
  • Author(s): Isao Ito
  • Organizer: The 3rd international congress on natural sciences.
  • Place of Presentation: 新潟大学 五十嵐キャンパス
  • Invited