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Stochastic neurocomputing with incorporating the survival strategies of micro-algae cells

Research Project

Project/Area Number 25280092
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Soft computing
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Ozasa Kazunari  国立研究開発法人理化学研究所, 前田バイオ工学研究室, 専任研究員 (10231234)

Research Collaborator Song Simon  Hanyang University, Department of Mechanical Engineering, Professor
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsソフトコンピューティング / 生物物理 / 微生物 / 生存戦略 / 確率的情報処理
Outline of Final Research Achievements

By using biological diversity and survival strategy for information processing, it is expected that more flexible processing and witty judgment can be realized on the computer. In this study, we studied the survival strategy behavior and diversity of the swimming micro-algae Euglena gracilis by experiments and aimed at implementing them as soft computing function. Neurocomputing with photo-resistive noise oscillators as state variables of the neurons and the particle simulation type neurocomputing were targeted. We realized the function to acquire approximate solutions one after another in a short time to the nearly NP-hard problems such as combinatorial optimization problems. Furthermore, stochastic neurocomputing was realized by a new approach of stochastic calculation rule application.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (41 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (12 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 8 results) Presentation (23 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results) Remarks (5 results)

  • [Int'l Joint Research] Hanyang University(韓国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Temporal change of photophobic step-up responses of Euglena gracilis investigated through motion analysis2017

    • Author(s)
      K.Ozasa, J.Won, S.Song, S.Tamaki, T.Ishikawa, M.Maeda
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 2 Pages: e0172813-e0172813

    • DOI

      10.1371/journal.pone.0172813

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Autonomous oscillation/separation of cell density artificially induced by optical interlink feedback as designed interaction between two isolated microalgae chips2016

    • Author(s)
      K.Ozasa, J.Won, S.Song, M.Maeda
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 24602-24602

    • DOI

      10.1038/srep24602

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Toxic Effect Monitoring by Analyzing Swimming Motions of Microbial Cells Confined in Microfluidic Chip with Micro-Trench Flow Injection2016

    • Author(s)
      K.Ozasa, J.Won, S.Song, M.Maeda
    • Journal Title

      Procedia Eng.

      Volume: 168 Pages: 1450-1453

    • DOI

      10.1016/j.proeng.2016.11.414

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Autonomous Pattern Formation of Micro-organic Cell Density with Optical Interlink between Two Isolated Culture Dishes2015

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Artificial Life

      Volume: 21 Issue: 2 Pages: 234-246

    • DOI

      10.1162/artl_a_00159

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Real-time analysis of chemotactic motion of Euglena cells confined in a microchip toxicity sensor2015

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Key Eng. Mater.

      Volume: 644 Pages: 185-188

    • DOI

      10.4028/www.scientific.net/kem.644.185

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chemical sensing via chemotaxis of Euglena confined in an isolated micro-aquarium2014

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Key Eng. Mater.

      Volume: 605 Pages: 95-98

    • DOI

      10.4028/www.scientific.net/kem.605.95

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analog Feedback in Euglena-Based Neural Network Computing ―Enhancing Solution-Search Capability through Reaction Threshold Diversity among Cells―2014

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Neurocomput.

      Volume: 140 Pages: 291-298

    • DOI

      10.1016/j.neucom.2014.03.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transient freezing behavior in photophobic responses of Euglena gracilis investigated in a microfluidic device2014

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Plant Cell Physiol.

      Volume: 55 Issue: 10 Pages: 1704-1712

    • DOI

      10.1093/pcp/pcu101

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Toxicity Sensing by Using Chemotactic Reaction of Microbial Cells Confined in Microfluidic Chip2014

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Procedia Eng.

      Volume: 87 Pages: 512-515

    • DOI

      10.1016/j.proeng.2014.11.422

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Euglena-based neurocomputing with two-dimensional optical feedback on swimming cells in micro-aquariums2013

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Appl. Soft Comput.

      Volume: 13 Pages: 527-538

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microfluidic Gas Sensing with Living Microbial Cells Confined in A Microaquarium2013

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Key Eng. Mater.

      Volume: 543 Pages: 431-434

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gas/liquid sensing via chemotaxis of Euglena cells confined in an isolated micro-aquarium2013

    • Author(s)
      Kazunari Ozasa、他
    • Journal Title

      Lab Chip

      Volume: 13 Pages: 4033-4039

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミドリムシの光応答に基づいたニューロコンピューティング2017

    • Author(s)
      尾笹一成
    • Organizer
      NI-SIGNAC-CCS合同研究会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] マイクロフルイディクスを利用した走化性の検証2017

    • Author(s)
      尾笹一成
    • Organizer
      第90回日本細菌学会総会、ワークショップ「ミクロな微生物社会を掴む新技術」
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Logic Pattern Operation Using Two Separated Groups of Euglena Cells in Microchips by Optical Crosslink Feedback2016

    • Author(s)
      K.Ozasa, J.Won, S.Song, M.Maeda
    • Organizer
      20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2016)
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Toxic Effect Monitoring by Analyzing Swimming Motions of Microbial Cells Confined in Microfluidic Chip with Micro-Trench Flow Injection2016

    • Author(s)
      K.Ozasa, J.Won, S.Song, M.Maeda
    • Organizer
      EuroSensors2016
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Euglena-Inspired Neurocomputing with 256 Photo-Responsive Noise Oscillators2016

    • Author(s)
      K.Ozasa, J.Won, S.Song, M.Maeda
    • Organizer
      Unconventional Computation and Natural Computation 2016 (UCNC2016)
    • Place of Presentation
      Manchester, UK
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Artificial Interaction between Two Isolated Micro-Algae Populations for Autonomous Pattern and Rhythm Formation2016

    • Author(s)
      K.Ozasa, J.Won, S.Song, M.Maeda
    • Organizer
      15th International Conference on the Synthesis and Simulation of Living Systems (ALife2016)
    • Place of Presentation
      Cancum, Mexico
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ユーグレナの光忌避運動にみるセルの性質の多様化2016

    • Author(s)
      尾笹一成、前田瑞夫
    • Organizer
      ユーグレナ研究会第32回研究集会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] ユーグレナの光忌避運動の変遷2015

    • Author(s)
      尾笹一成
    • Organizer
      ユーグレナ研究会第31回研究集会
    • Place of Presentation
      宮崎
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Real-Time Motion Analysis of Euglena Cells Swimming in a Microfluidic Chip for Environmental Toxicity Biosensing2015

    • Author(s)
      Kazunari Ozasa
    • Organizer
      19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2015)
    • Place of Presentation
      Gyeongju, Korea
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 光フィードバックによるミドリムシへの人工フェロモン効果2015

    • Author(s)
      尾笹一成
    • Organizer
      日本物理学会 2015 年秋季大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Adaptation of Euglena Cells to Blue Light Investigated with Optical Feedback System2015

    • Author(s)
      Kazunari Ozasa
    • Organizer
      Multinational Congress on Microscopy 2015 (MCM2015)
    • Place of Presentation
      Eger, Hungary
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences in photophobic response between Euglena gracilis and Chlamydomonas reinhardtii2015

    • Author(s)
      Kazunari Ozasa
    • Organizer
      10th European Biophysics Congress (EBSA2015)
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell Multiplication and Movement Analysis of Swimming Euglena Confined in a Flow-isolated Micro-aquarium2014

    • Author(s)
      Kazunari Ozasa
    • Organizer
      18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2014)
    • Place of Presentation
      Austin, USA
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミドリムシの化学走性を利用した細胞毒性モニターチップ2014

    • Author(s)
      尾笹一成
    • Organizer
      第75回応用物理学会学術講演会
    • Place of Presentation
      札幌、北海道大学
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Toxicity Sensing by Using Chemotactic Reaction of Microbial Cells Confined in Microfluidic Chip2014

    • Author(s)
      Kazunari Ozasa
    • Organizer
      Eurosensors 2014
    • Place of Presentation
      Brescia, Italy
    • Year and Date
      2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Toxicity sensor using Euglena living cells confined in a microfluidic chip2014

    • Author(s)
      Kazunari Ozasa
    • Organizer
      RSC-Tokyo International Conference
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dynamic Connection-Path Network Computing by Artificial Pheromone Effects for Euglena Cells2014

    • Author(s)
      Kazunari Ozasa
    • Organizer
      Unconventional Computation and Natural Computation 2014 (UCNC2014)
    • Place of Presentation
      Ontario, Canada
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Real-time analysis of chemotactic motion of Euglena cells confined in a microchip toxicity sensor2014

    • Author(s)
      Kazunari Ozasa
    • Organizer
      4th International Conference on Materials and Applications for Sensors and Transducers (ICMAST2014)
    • Place of Presentation
      Bilbao, Spain
    • Year and Date
      2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optical interlink-feedback between two isolated culture dishes of Euglena toward cooperative/competitive bio-computing2013

    • Author(s)
      Kazunari Ozasa
    • Organizer
      Unconventional Computation and Natural Computation 2013 (UCNC2013
    • Place of Presentation
      Milano, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chemical sensing via chemotaxis of Euglena confined in an isolated micro-aquarium2013

    • Author(s)
      Kazunari Ozasa
    • Organizer
      3rd International Conference on Materials and Applications for Sensors and Transducers (ICMAST2013)
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2013 Annual Research Report
  • [Presentation] Electromagnetic Wave Sensing of Euglena gracilis Viability and Quantification2013

    • Author(s)
      Kazunari Ozasa
    • Organizer
      3rd International Conference on Materials and Applications for Sensors and Transducers (ICMAST2013)
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cell Movement Tracking of Euglena Gracilis Confined/Multiplying in An Isolated Micro-Aquarium2013

    • Author(s)
      Kazunari Ozasa
    • Organizer
      EMBO/EMBL Symposium 2013: Seeing is Believing - Imaging the Processes of Life
    • Place of Presentation
      Heidelberg, Germany
    • Related Report
      2013 Annual Research Report
  • [Presentation] Introduction of Artificial Pheromone Effects on Euglena Cells toward Ant Colony Optimization Experiments2013

    • Author(s)
      Kazunari Ozasa
    • Organizer
      2nd International Conference on the Theory and Practice of Natural Computing (TPNC 2013)
    • Place of Presentation
      Caceres, Spain
    • Related Report
      2013 Annual Research Report
  • [Remarks] K.Ozasa home

    • URL

      http://www.k-ozasa.net/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 理化学研究所 前田バイオ工学研究室

    • URL

      http://www.riken.jp/lab-www/bioengineering/

    • Related Report
      2016 Annual Research Report
  • [Remarks] Multiscale flow lab. home

    • URL

      http://iroon14.cafe24.com/xe/home

    • Related Report
      2016 Annual Research Report
  • [Remarks] Kazunari Ozasa : Home

    • URL

      http://www.k-ozasa.net/

    • Related Report
      2015 Annual Research Report
  • [Remarks] Kazunari Ozasa : Research A

    • URL

      http://www.k-ozasa.net/index.html

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2022-01-31  

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