Elucidation of next-generation toxicity having highly detective and concetrated homeostatic disruptive chemicals in human and food
| Project/Area Number |
25281032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental impact assessment
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| Research Institution | Setsunan University |
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Principal Investigator |
Ohta Souichi 摂南大学, 薬学部, 教授 (10213729)
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| Co-Investigator(Kenkyū-buntansha) |
KAKUTANI HIDEKI 摂南大学, 薬学部, 助教 (00581414)
EMA AKIYAMA 摂南大学, 薬学部, 助教 (50581401)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 内分泌攪乱 / 性ホルモン / ダイオキシン / PFOS / 恒常性攪乱 / 恒常性攪乱物質 / TBBPA / TCDD / 免疫かく乱 / 経世代毒性影響 / 性ホルモン定量 |
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| Outline of Final Research Achievements |
There are yet many any questions about the toxicity influence on highly advanced functions such as sex hormone secretion or the immune system in human body by environmental pollutants intake with a very small amount from food. In this study, when we administrated PFOS or TCDD to mice each, it was analyze in sex hormone levels in the blood and evaluate their disruption effect As a result, if we assumed a biosynthesis pathway to Androgen and Estrogen which went by way of Progestin from Cholesterol, it was estimated the sex hormone disruption effect having PFOS and TCDD exist the Androgen synthetic pathway side more downstream than Progestin located upstream of the synthetic pathway.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk2015
Author(s)
Akiyama, E., Kakutani, H., Nakao, T., Motomura, Y., Takano, Y., Sorakubo, R., Mizuno, A., Aozasa, O., Tachibana, K., Doi, T., Ohta, S.
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Journal Title
Environmenta Research
Volume: 140
Pages: 157-164
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother’s milk in Japan.2014
Author(s)
Akiyama, E., Kakutani, H., Nakao, T., Motomura, Y., Takano, Y., Sorakubo, R., Mizuno, A., Aozasa, O., Tachibana, K., Doi, T., Ohta, S.
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Journal Title
Toxicology
Volume: 324
Pages: 157-164
DOI
Related Report
Peer Reviewed
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