| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Outline of Final Research Achievements |
The validity of the processed food frequency questionnaire (PFFQ) to estimate amount of phosphorus intake used in this study was verified. The amounts of phosphorus estimated by the PFFQ were correlated with those calculated from diet-records, which showed the validity of this questionnaire.
In this study we investigated the effect of inorganic phosphorus containing in foods as additives on the phosphorus metabolism and the vascular endothelial function. The test meals rich in inorganic phosphorus or organic phosphorus were administered to the subjects, and then the Flow Mediated Dilation (FMD) and the phosphorus metabolic markers were measured. After intake of the high inorganic phosphorus meal, plasma phosphorus level was significantly elevated, and the FMD was deteriorated, compared with the high organic phosphorus meal. It was suggested that ingestion of inorganic phosphorus contained as food additives impaired the vascular endothelial function.
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