The development of new biomarkers to assess the dietary environments concerned to the phosphorus metabolic abnormalities in the diabetic end-stage renal diseases
| Project/Area Number |
25282025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Hyogo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO MIKIKO 兵庫県立大学, 環境人間学部, 教授 (50314852)
NITTA YOKO 岡山県立大学, 保健福祉学部, 准教授 (70403318)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 糖尿病末期腎症 / 高リン血症 / 血管内皮機能 / リン代謝マーカー / 血液透析 / 血流依存性血管拡張反応 / リン摂取量 / リン代謝調節因子 |
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| Outline of Final Research Achievements |
The validity of the processed food frequency questionnaire (PFFQ) to estimate amount of phosphorus intake used in this study was verified. The amounts of phosphorus estimated by the PFFQ were correlated with those calculated from diet-records, which showed the validity of this questionnaire.
In this study we investigated the effect of inorganic phosphorus containing in foods as additives on the phosphorus metabolism and the vascular endothelial function. The test meals rich in inorganic phosphorus or organic phosphorus were administered to the subjects, and then the Flow Mediated Dilation (FMD) and the phosphorus metabolic markers were measured. After intake of the high inorganic phosphorus meal, plasma phosphorus level was significantly elevated, and the FMD was deteriorated, compared with the high organic phosphorus meal. It was suggested that ingestion of inorganic phosphorus contained as food additives impaired the vascular endothelial function.
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Report
(4 results)
Research Products
(69 results)
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[Presentation] Varietal Differences in Transcript and Protein Levels of Strawberry Allergen Fra a 12013
Author(s)
Narukami M, Futsuki D, Nabe T, Nitta Y, Tsuruta H, Yamasaki K, Iduhara M, Noguchi Y, Uno Y
Organizer
The American Society for Horticultural Science 2013 Annual Conference
Place of Presentation
JW Marriott Desert Springs Palm Desert, CA, USA
Related Report
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