| Project/Area Number |
25282029
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKINO Jun-ichi 広島国際大学, 薬学部, 助教 (00440529)
TAKATA Takanobu 金沢医科大学, 総合医学研究所, 助教 (20515308)
UEDA Tadashi 金沢医科大学, 総合医学研究所, 助教 (80151794)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 食習慣 / NAFLD / NASH / TAGE / 生活習慣病 / 食生活 |
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| Outline of Final Research Achievements |
With the current widespread introduction of a Western lifestyle, the number of patients with nonalcoholic fatty liver disease (NAFLD) has rapidly increased, contributing to increases in the liver cancer- or cardiovascular disease-related mortality rates. However, the etiology remains to be clarified. Our previous study indicated that toxic AGEs (TAGE), which may be primarily involved in lifestyle-related diseases (LSRD), were synthesized in vivo in the presence of postprandial hyperglycemia or after the excessive ingestion of fructose and dietary AGEs.
This study showed that the characteristics of the current diet (excessive ingestion of glucose/fructose/high-AGE drinks or foods) promoted the generation/accumulation of TAGE in hepatocytes or myocardial cells, closely contributing to the onset/deterioration of each condition, and that the blood TAGE level reflected the grade of the condition. Therefore, the results of this study may promote new strategies to prevent LSRD.
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