Association between characteristics of current diet and onset/deterioration of non-alcoholic fatty liver disease

• Project/Area Number: 25282029
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanazawa Medical University
• Principal Investigator: TAKEUCHI Masayoshi 金沢医科大学, 総合医学研究所, 教授 (20154982)
• Co-Investigator(Kenkyū-buntansha): TAKINO Jun-ichi 広島国際大学, 薬学部, 助教 (00440529) ; TAKATA Takanobu 金沢医科大学, 総合医学研究所, 助教 (20515308) ; UEDA Tadashi 金沢医科大学, 総合医学研究所, 助教 (80151794)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 食習慣 / NAFLD / NASH / TAGE / 生活習慣病 / 食生活

Outline of Final Research Achievements

With the current widespread introduction of a Western lifestyle, the number of patients with nonalcoholic fatty liver disease (NAFLD) has rapidly increased, contributing to increases in the liver cancer- or cardiovascular disease-related mortality rates. However, the etiology remains to be clarified. Our previous study indicated that toxic AGEs (TAGE), which may be primarily involved in lifestyle-related diseases (LSRD), were synthesized in vivo in the presence of postprandial hyperglycemia or after the excessive ingestion of fructose and dietary AGEs.
This study showed that the characteristics of the current diet (excessive ingestion of glucose/fructose/high-AGE drinks or foods) promoted the generation/accumulation of TAGE in hepatocytes or myocardial cells, closely contributing to the onset/deterioration of each condition, and that the blood TAGE level reflected the grade of the condition. Therefore, the results of this study may promote new strategies to prevent LSRD.

Research Products

• [Journal Article] Acute effects of statin on reduction of angiopoietin-like 2 and glyceraldehyde-derived glycation end-products levels in patients with acute myocardial infarction: a message grom SAMIT (Statin for Acute Myocardial Infarction Trial). (2016)
  • Author(s): Shimomura M, Oyama JI, Takeuchi M, Shibata Y, Yamamoto Y, Kawasaki T, Komoda H, Kodama K, Sakuma M, Toyoda S, Inoue Y, Mine D, Natsuaki M, Komatsu A, Hikichi Y, Yamagishi SI, Inoue T, Node K.
  • Journal Title: Heart Vessels Volume: 印刷中
  • Peer Reviewed
• [Journal Article] The association between glyceraldehyde-derived advanced glycation end-roducts and colorectal cancer risk. (2015)
  • Author(s): Kong SY, Takeuchi M,他４６名（２/４８）
  • Journal Title: Cancer Epidemiol. Biomarkers Prev. Volume: ２４ Issue: 12 Pages: 1855-1863
  • DOI: 10.1158/1055-9965.epi-15-0422
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Assessment of the concentrations of total sugars and glucose in beverages that are Commonly Consumed in Japan. (2015)
  • Author(s): Takeuchi M, Takino J, Shirai H, Kawakami M, Furuno S, Kobayashi Y.
  • Journal Title: Nutr. Food Technol Volume: １ Pages: 2-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Elevation of serum levels of advanced glycation end products in patients with non-B or non-C hepatocellular carcinoma. (2015)
  • Author(s): Kan H, Yamagishi S, Ojima A, Fukami K, Ueda S, Takeuchi M, Hyogo H, Aikata H, Chayama K.
  • Journal Title: J. Clin. Lab. Anal. Volume: ２９ Issue: 6 Pages: 480-484
  • DOI: 10.1002/jcla.21797
  • Peer Reviewed
• [Journal Article] Contribution of toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma. (2015)
  • Author(s): Takino J, Nagamine K, Hori T, Sakasai-Sakai A, Takeuchi M.
  • Journal Title: World J. Hepatol. Volume: ７ Issue: 23 Pages: 2459-2469
  • DOI: 10.4254/wjh.v7.i23.2459
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Glyceraldehyde caused Alzheimer’s disease-like alterations in levels of diagnostic markers in SH-SY5Y cells. (2015)
  • Author(s): Koriyama Y, Furukawa A, Muramatsu M, Takino J, Takeuchi M.
  • Journal Title: Sci. Rep. Volume: ５ Issue: 1 Pages: 13313-13313
  • DOI: 10.1038/srep13313
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Toxic AGEs (TAGE) theory in the pathogenesis of NAFLD and ALD. (2015)
  • Author(s): Takeuchi M, Sakasai-Sakai A, Takino J, Takata T, Ueda T, Tsutsumi M.
  • Journal Title: Int. J. Diabetes Clin. Res. Volume: ２ Pages: 4-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH. (2015)
  • Author(s): Takeuchi M, Sakasai-Sakai A, Takata T, Ueda T, Takino J, Tsutsumi M, Hyogo H, Yamagishi S.
  • Journal Title: Med. Hypotheses Volume: ８４ Issue: 5 Pages: 490-493
  • DOI: 10.1016/j.mehy.2015.02.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical and Biochemical Factors Associated With Area and Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT. (2015)
  • Author(s): Tahara N, Yamagishi S, Kodama N, Tahara A, Honda A, Nitta Y, Igata S, Matsui T, Takeuchi M, Kaida H, Kurata S, Abe T, Fukumoto Y.
  • Journal Title: J Clin Endocrinol Metab. Volume: 100 Issue: 5 Pages: E739-E747
  • DOI: 10.1210/jc.2014-3896
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor levels indicate carbonyl stress in patients with schizophrenia. (2015)
  • Author(s): Takeda M, Ohnuma T, Takeuchi M, Katsuta N, Maeshima H, Takebayashi Y, Higa M, Nakamura T, Nishimon S, Sannohe T, Hotta Y, Hanzawa R, Higashiyama R, Shibata N, Gohda T, Suzuki Y, Yamagishi S, Tomino Y, Arai H.
  • Journal Title: Neurosci. Lett. Volume: ５９３ Pages: 51-55
  • DOI: 10.1016/j.neulet.2015.03.002
  • Peer Reviewed
• [Journal Article] 生活習慣病の発症・進展におけるToxic AGEs (TAGE) の関与：－新たな予防戦略－～食事性AGEsおよび糖毒性の真実～ (2015)
  • Author(s): 竹内正義、瀧野純一、逆井（坂井）亜紀子、高田尊信、上田忠司
  • Journal Title: 金医大誌 Volume: ４０ Pages: 95-103
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 現代の食生活に潜む落とし穴～飲食物中AGEs及び糖毒性の真実～ (2015)
  • Author(s): 竹内正義、瀧野純一、古野理美、白井ひかり、河上美穂子、村松充、小林由佳
  • Journal Title: 日本未病システム学会雑誌 Volume: 21 Pages: 53-58
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 脂質異常患者に対する脂質低下療法がGlycer-AGEsにもたらす影響 (2015)
  • Author(s): 廣正修一、竹内正義
  • Journal Title: 診療と新薬 Volume: 52 Pages: 513-519
  • Peer Reviewed
• [Journal Article] 不妊治療バイオマーカーとしてのToxic AGEs (TAGE) の有用性 (2015)
  • Author(s): 逆井（坂井）亜紀子、神野正雄、竹内正義
  • Journal Title: 日本未病システム学会雑誌 Volume: 21 Pages: 93-96
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Assessment of the contents of various advanced glycation end-products in commonly consumed beverages and foods in Japanese culture. (2015)
  • Author(s): Takeuchi M, Takino J, Furuno S, Shirai H, Kawakami M, Muramatsu M, Kobayashi Y, Yamagishi S.
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0118652-e0118652
  • DOI: 10.1371/journal.pone.0118652
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In vivo identification of nonalcoholic fatty liver disease-related protein hnRNPM. (2015)
  • Author(s): Takino J, Nagamine K, Takeuchi M, Hori T.
  • Journal Title: World J. Gastroenterol. Volume: 21 Issue: 6 Pages: 1784-1793
  • DOI: 10.3748/wjg.v21.i6.1784
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues by FDG-PET/CT. (2015)
  • Author(s): Tahara N, Yamagishi SI, Kodama N, Tahara A, Honda A, Nitta Y, Igata S, Matsui T, Takeuchi M, Kaida H, Kurata S, Abe T, Fukumoto Y
  • Journal Title: J. Clin. Endocrinol. Metab. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. (2015)
  • Author(s): Fukami K, Yamagishi S, Sakai K, Kaida Y, Yokoro M, Ueda S, Wada Y, Takeuchi M, Shimizu M, Yamazaki H, Okuda S.
  • Journal Title: J. Cardiovasc. Pharmacol. Volume: 65. Issue: 3 Pages: 289-295
  • DOI: 10.1097/fjc.0000000000000197
  • Peer Reviewed / Open Access
• [Journal Article] Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function. (2015)
  • Author(s): Kajikawa M, Nakashima A, Fujimura N, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Oda N, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Noma K, Takeuchi M, Matsui T, Yamagishi S, Higashi Y.
  • Journal Title: Diabetes Care. Volume: 38(1) Issue: 1 Pages: 119-25
  • DOI: 10.2337/dc14-1435
  • Peer Reviewed
• [Journal Article] Involvement of the TAGE-RAGE system in NASH: Novel treatment strategies. (2014)
  • Author(s): Takeuchi M, Takino J, Sakasai-Sakai A, Takata T, Ueda T, Tsutsumi M, Hyogo H, Yamagishi S.
  • Journal Title: World J. Hepatol Volume: 6 Issue: 12 Pages: 880-893
  • DOI: 10.4254/wjh.v6.i12.880
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde derived-advanced glycation end product formation. (2014)
  • Author(s): Dong Z, Iwata D, Kitaichi N, Takeuchi M, Sato M, Endo N, Iwabuchi K, Ando R, Fukuhara J, Kinoshita S, Lennikov A, Kitamura M, Mizuuchi K, Kanda A, Noda K, Namba K, Yamagishi S, Ohno S, Ishida S
  • Journal Title: J Leukoc Biol Volume: 96 Issue: 6 Pages: 1077-1085
  • DOI: 10.1189/jlb.3a0513-288rrr
  • Peer Reviewed / Open Access
• [Journal Article] Switching to multiple daily injection therapy with glulisine improves glycemic control, vascular damage and treatment satisfaction in basal insulin glargine-injected diabetic patients. (2014)
  • Author(s): Yanagisawa K, Ashihara J, Obata S, Wada N, Takeuchi M, Nishino Y, Maeda S, Ishibashi Y, Yamagishi S.
  • Journal Title: Diabetes Metab. Res. Rev. Volume: 30 Issue: 8 Pages: 693-700
  • DOI: 10.1002/dmrr.2537
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice (2014)
  • Author(s): Ayako Ojima, Takanori Matsui, Sayaka Maeda, Masayoshi Takeuchi, Hiroyoshi Inoue, Yuichiro Higashimoto, Sho-ichi Yamagishi
  • Journal Title: Laboratory Investigation Volume: 94(4) Issue: 4 Pages: 422-429
  • DOI: 10.1038/labinvest.2014.5
  • Peer Reviewed / Open Access
• [Journal Article] Sulforaphane inhibits advanced glycation end product-induced pericyte damage by reducing expression of receptor for advanced glycation end products. (2014)
  • Author(s): Maeda S, Matsui T, Ojima A, Takeuchi M, Yamagishi S.
  • Journal Title: Nutr. Res. Volume: 34 Issue: 9 Pages: 807-813
  • DOI: 10.1016/j.nutres.2014.08.010
  • Peer Reviewed
• [Journal Article] Linagliptin blocks renal damage in type 1 diabetic rats by suppressing advanced glycation end products-receptor axis. (2014)
  • Author(s): Nakashima S, Matsui T, Takeuchi M, Yamagishi S.
  • Journal Title: Horm. Metab. Res. Volume: 46 Issue: 10 Pages: 717-721
  • DOI: 10.1055/s-0034-1371892
  • Peer Reviewed
• [Journal Article] Effect of statins on the serum soluble form of receptor for advanced glycation end-products and its association with coronary atherosclerosis in patients with angina pectoris. (2014)
  • Author(s): Nozue T, Yamagishi S, Takeuchi M, Hirano T, Yamamoto S, Tohyama S, Fukui K, Umezawa S, Onishi Y, Kunishima T, Hibi K, Terashima M, Michishita I.
  • Journal Title: IJC Metabolic & Endocrine Volume: 4 Pages: 47-52
  • Peer Reviewed / Open Access
• [Journal Article] Possible effects of glimepiride beyond glycemic control in patients with type 2 diabetes: a preliminary report. (2014)
  • Author(s): Nakamura I, Oyama J, Komoda H, Shiraki A, Sakamoto Y, Taguchi I, Hiwatashi A, Komatsu A, Takeuchi M, Yamagishi S, Inoue T, Node K.
  • Journal Title: Cardiovasc Diabetol. Volume: 13 Issue: 1 Pages: 15-15
  • DOI: 10.1186/1475-2840-13-15
  • Peer Reviewed
• [Journal Article] Advanced glycation end products impair glucose-induced insulin secretion from rat pancreatic β-cells. (2014)
  • Author(s): Hachiya H, Miura Y, Inoue K, Park KH, Takeuchi M, Kubota K.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 21 Issue: 2 Pages: 624-630
  • DOI: 10.1002/jhbp.12
  • Peer Reviewed
• [Journal Article] Presence of glyceraldehyde-derived advanced glycation end-products in the liver of insulin-resistant mice. (2013)
  • Author(s): Ebata Y, Takino J, Tsuchiya H, Sakabe T, Ikeda Y, Hama S, Kogure K, Takeuchi M, Shiota G.
  • Journal Title: Int J Vitam Nutr Res. Volume: 83 Issue: 2 Pages: 137-141
  • DOI: 10.1024/0300-9831/a000150
  • Peer Reviewed
• [Journal Article] Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells (2013)
  • Author(s): Higashimoto, Y., Matsui, T., Nishino, Y., Taira, J., Inoue, H., Takeuchi, M., Yamagishi, S.I.
  • Journal Title: Microvasc. Res. Volume: 90 Pages: 64-70
  • DOI: 10.1016/j.mvr.2013.08.010
  • Peer Reviewed
• [Journal Article] Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) - receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes. (2013)
  • Author(s): Sakata K, Hayakawa M, Yano Y, Tamaki N, Yokota N, Eto T, Watanabe R, Hirayama N, Matsuo T, Kuroki K, Sagara S, Mishima O, Koga M, Nagata N, Nishino Y, Kitamura K, Kario K, Takeuchi M, Yamagishi S.
  • Journal Title: Diabetes Metab Res Rev. Volume: 29 Issue: 8 Pages: 624-630
  • DOI: 10.1002/dmrr.2437
  • Peer Reviewed
• [Journal Article] DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy. (2013)
  • Author(s): Kaida Y,Fukami K, Matsui T,HigashimotoY,NishinoY,ObaraN,Nakayama Y, Ando R, Toyonaga M, Ueda S,TakeuchiM,InoueH,OkudaS,Yamagishi SI
  • Journal Title: Diabetes Volume: 62 Issue: 9 Pages: 3241-3250
  • DOI: 10.2337/db12-1608
  • Peer Reviewed
• [Journal Article] Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease. (2013)
  • Author(s): Hayashi N, George J, Takeuchi M, Fukumura A, Toshikuni N, Arisawa T, Tsutsumi M.
  • Journal Title: PLoS One. Volume: 8 Issue: 7 Pages: e70034-e70034
  • DOI: 10.1371/journal.pone.0070034
  • Peer Reviewed
• [Presentation] 培養心筋細胞における細胞内TAGE生成／蓄積と心筋細胞障 (2016)
  • Author(s): 上田忠司、高田尊信、竹内正義
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] ヒト膵管癌培養細胞における細胞内TAGE蓄積と細胞障害関連蛋白質の探索 (2016)
  • Author(s): 高田尊信、逆井（坂井）亜紀子、上田忠司、竹内正義
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] Glycer-AGEsによる神経細胞障害とアルツハイマー病バイオマーカー変化 (2016)
  • Author(s): 郡山恵樹、古川絢子、瀧野純一、竹内正義
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] NAFLDとALDの発症・進展におけるToxic AGEs (TAGE) の関与 (2016)
  • Author(s): 瀧野純一、長嶺憲太郎、堀隆光、堤幹宏、竹内正義
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] 糖化hnRNPMによる遺伝子発現変化の解析 (2016)
  • Author(s): 長峰憲太郎、瀧野純一、永井真也、山根惇、平石勇、竹内正義、堀隆光
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] グリセルアルデヒド誘導糖化皮膚モデルにおける化合物皮膚透過性の評価 (2016)
  • Author(s): 関田真理絵、横田真美、竹内正義、徳留嘉寛
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] Toxic AGEs はヒト真皮線維芽細胞のECM合成のバランスを崩す (2016)
  • Author(s): 西川功征、水谷多恵子、岡野由利、竹内正義、正木仁
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] Glycer-AGE化タンパク質からのアルツハイマー病バイオマーカー探索変化 (2016)
  • Author(s): 鈴木啓太、古川絢子、竹内正義、郡山恵樹
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-27
• [Presentation] NAFLDとALDの発症・進展におけるToxic AGEs (TAGE) の関与 (2016)
  • Author(s): 竹内正義、瀧野純一、堤幹宏
  • Organizer: 第35回アルコール医学生物学研究会学術集会
  • Place of Presentation: リーガロイヤルホテル東京（東京都新宿区）
  • Year and Date: 2016-01-22
• [Presentation] The presence of glyceraldehyde-derived AGEs in the skin (2015)
  • Author(s): Mami Yokota, Yuri Okano, Hitoshi Masaki, Masayoshi Takeuchi, Yoshihiro Tokudome
  • Organizer: 日本研究皮膚科学会第40回年次学術大会・総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2015-12-11
• [Presentation] 非アルコール性脂肪性肝疾患 (NAFLD) の診断マーカーの探索 (2015)
  • Author(s): 長嶺憲太郎、瀧野純一、竹内正義、堀隆光
  • Organizer: Biochemistry and Molecular Biology (BMB) 2015，第38回日本分子生物学会年会／第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] 抗糖化機能性食品 ヒシエキスによるART妊娠率の著しい改善：ART反復不成功の高齢不妊に対する終末糖化産物低下の重要性 (2015)
  • Author(s): 神野正雄、渡邊愛子、畠山尚久、合田友哉、日浦理絵、竹下祥子、上村知広、山田道生、竹内正義
  • Organizer: 第33回日本受精着床学会総会・学術講演会
  • Place of Presentation: TFTホール（東京都江東区）
  • Year and Date: 2015-11-26
• [Presentation] 飲食物中AGEs及び糖毒性の真実～現代の食生活に潜む落とし穴～ (2015)
  • Author(s): 竹内正義、古野理美、白井ひかり、河上美穂子、村松充、小林由佳、山岸昌一、瀧野純一
  • Organizer: 第22回日本未病システム学会総会学術総会
  • Place of Presentation: 北海道大学学術交流会館（北海道札幌市）
  • Year and Date: 2015-10-11
• [Presentation] 糖化を防いでアンチエイジング～現代の食習慣に潜むわな～ (2015)
  • Author(s): 竹内正義
  • Organizer: Beautiful Life－第12章－～いきいきと輝いたセカンドライフを～ 奈良新聞社主催市民講演会 基調講演
  • Place of Presentation: 奈良県橿原文化会館（奈良県橿原市）
  • Year and Date: 2015-09-19
  • Invited
• [Presentation] オンライン血液透析濾過の血清グリセルアルデヒド由来AGEs（TAGE）への効果 (2015)
  • Author(s): 中澤了一、清水洋一、大川智、齋藤佑司、柏原英彦、小野隆、松金隆夫、渋谷泰史、東仲宣、竹内正義
  • Organizer: 第60回日本透析医学会学術集会・総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-26
• [Presentation] 飲食物中AGEs及び糖毒性の真実～現代の食生活に潜む落とし穴～ (2015)
  • Author(s): 竹内正義、古野理美、白井ひかり、河上美穂子、村松充、小林由佳、山岸昌一、瀧野純一
  • Organizer: 第15回日本抗加齢医学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2015-05-29
• [Presentation] The effect of predilution on-line haemodiafiltration on serum glyceraldehyde-derived advanced glycation end-products (Toxic AGEs: TAGE) in haemodialysis patients. (2015)
  • Author(s): Ryoichi Nakazawa, Yoichi Shimizu, Satoshi Ohkawa, Yuji Saito, Hidehiko Kashiwabara, Mutsumi Ono, Takao Matsugane, Yasushi Shibuya, Nakanobu Azuma, Masayoshi Takeuchi
  • Organizer: European Renal Association (ERA)-Europian Dialysis and transplant Association (EDTA) 2015
  • Place of Presentation: ExCeL London (London, United Kingdom)
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] 飲食物中AGEs及び糖毒性の真実～新たな食事指導の概念～ (2015)
  • Author(s): 竹内正義、瀧野純一、古野理美、白井ひかり、河上美穂子、村松充、小林由佳、山岸昌一
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関グランドホテル（山口県下関市）
  • Year and Date: 2015-05-21
• [Presentation] アルコール性肝障害とNAFLDの病態に関与する終末糖化産物： AA-AGEsとGA-AGEsに関する検討 (2015)
  • Author(s): 福村敦、竹内正義、堤幹宏
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-05-21
• [Presentation] 真皮線維芽細胞の機能に及ぼすToxic AGEsの作用 (2015)
  • Author(s): 西川攻征、水谷多恵子、岡野由利、竹内正義、正木仁
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学他（兵庫県神戸市）
  • Year and Date: 2015-03-28
• [Presentation] 飲食物中AGEs及び糖毒性の真実 (2015)
  • Author(s): 瀧野純一、永井真也、山根惇、古野理美、白井ひかり、河上美穂子、村松充、小林由佳、竹内正義
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学他（兵庫県神戸市）
  • Year and Date: 2015-03-26
• [Presentation] 糖化のターゲット蛋白質であるhnRNPMの解析 (2015)
  • Author(s): 山根惇、永井真也、瀧野純一、長峰憲太郎、竹内正義、堀隆光
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学他（兵庫県神戸市）
  • Year and Date: 2015-03-26
• [Presentation] 不妊治療バイオマーカーとしてのToxic AGEs (TAGE) の有用性 (2015)
  • Author(s): 竹内正義、逆井（坂井）亜紀子、神野正雄
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学他（兵庫県神戸市）
  • Year and Date: 2015-03-26
• [Presentation] 不妊治療バイオマーカーとしてのToxic AGEs (TAGE) の有用性 (2014)
  • Author(s): 竹内正義、逆井（坂井）亜紀子、神野正雄
  • Organizer: 第21回日本未病システム学会学術総会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府大阪市）
  • Year and Date: 2014-11-01
• [Presentation] DPP-4阻害剤アナグリプチンの酸化ストレス抑制を介した血管障害抑制機序の解明 (2014)
  • Author(s): 堀英生、永味千枝、菊池千草、竹内正義、松永民秀
  • Organizer: 第88回日本糖尿病学会中部地方会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-10-26
• [Presentation] 2型糖尿病モデルラット大腿動脈におけるAGEsによるスーパーオキシド産生増加およびプラバスタチンによる抑制効果機序の解明 (2014)
  • Author(s): 堀英生、永味千枝、菊池千草、竹内正義、松永民秀
  • Organizer: 第24回日本医療薬学会年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2014-09-27
• [Presentation] 糖化を防いで生活習慣病予防～Toxic AGEs (TAGE) 病因説からみた新たな予防/治療戦略～ (2014)
  • Author(s): 竹内正義
  • Organizer: NPO法人北陸ライフケアクラスター研究会
  • Place of Presentation: 金沢都ホテル（石川県金沢市）
  • Year and Date: 2014-06-20
  • Invited
• [Presentation] 不妊治療バイオマーカーとしてのToxic AGEs (TAGE) (2014)
  • Author(s): 逆井（坂井）亜紀子、神野正雄、竹内正義
  • Organizer: 第14回日本抗加齢医学会総会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-06-06
• [Presentation] 非B非C型肝癌におけるAGE測定の意義 (2014)
  • Author(s): 菅宏美、兵庫秀幸、藤野初江、福原崇之、本田洋二、苗代典昭、宮本大輔、河岡友和、拓植雅貴、平松憲、今村道雄、川上由育、相方浩、茶山一彰、山岸昌一、竹内正義
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ（東京都千代田区）
  • Year and Date: 2014-05-30
• [Presentation] 終末糖化産物特異的DNAアプタマーは、ヌードマウスにおけるメラノーマ増殖を抑制する (2014)
  • Author(s): 松井孝憲、尾崎亜弥子、前田沙耶香、竹内正義、東元佑一郎、山岸昌一
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-05-23
• [Presentation] 糖化を防いで生活習慣病予防～Toxic AGEs (TAGE) 病因説からみた新たな予防/治療戦略～ (2014)
  • Author(s): 竹内正義
  • Organizer: 第63回日本医学検査学会
  • Place of Presentation: 朱鷺メッセ新潟コンベンションセンター（新潟県新潟市）
  • Year and Date: 2014-05-18
  • Invited
• [Presentation] DNA-aptamer raised against RAGE blocks the progression of experimental diabetic neuropathy. (2014)
  • Author(s): Kensei Taguchi, Kei Fukami, Sho-ichi Yamagishi, Yuichiro Higashimoto, Miyuki Yokoro, Nana Obara, Ryotaro Ando, Yosuke Nakayama, Takanori Matsui, Masayoshi Takeuchi, Seiji Ueda, Seiya Okuda.
  • Organizer: The 14th Asian Pacific Congress of Nephrology (APCN 2014) 2014
  • Place of Presentation: Shinagawa Prince Hotel（東京都港区）
  • Year and Date: 2014-05-15
• [Presentation] 糖化を防いで生活習慣病予防～Toxic AGEs (TAGE) 病因説からみた新たな予防/治療戦略～ (2014)
  • Author(s): 竹内正義
  • Organizer: Grand Design by Japan, 2014
  • Place of Presentation: 慶應義塾大学日吉キャンパス（神奈川県横浜市）
  • Year and Date: 2014-04-13
  • Invited
• [Presentation] 高フルクトース曝露による細胞内Glycer-AGEsの形成 (2014)
  • Author(s): 瀧野純一、長峰憲太郎、竹内正義、堀隆光
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本市総合体育館
• [Presentation] 新しい重症卵巣機能障害の治療法：sitagliptin による食後糖代謝是正は卵胞・胚発育，妊娠率を改善する (2013)
  • Author(s): 神野正雄，渡邉愛子，竹内正義，日浦理絵，廣濱準，畠山尚久
  • Organizer: 第57回日本生殖医学会学術講演会・総会
  • Place of Presentation: 長崎市長崎ブリックホール
• [Presentation] 非アルコール性脂肪肝炎（NASH）の発症・進展におけるtoxic AGEs (TAGE) の関与 (2013)
  • Author(s): 竹内正義，瀧野純一，兵庫秀幸，山岸昌一
  • Organizer: 第20回日本未病システム学会学術総会
  • Place of Presentation: 東京都千代田区学術総合センター
• [Presentation] 未病マーカーとしてのtoxic AGEs (TAGE) の有用性 (2013)
  • Author(s): 竹内正義，兵庫秀幸，山岸昌一，神野正雄
  • Organizer: 第20回日本未病システム学会学術総会
  • Place of Presentation: 東京都千代田区学術総合センター
• [Presentation] 肥満２型糖尿病モデルWBN/Kob-fattyラットの糖尿病性腎症の経過と腎臓におけるToxic AGEsの局在について (2013)
  • Author(s): 秋元敏雄，丸山基世，益田幸成，岡田嘉仁，竹内正義，鈴木龍一郎，福生吉裕
  • Organizer: 第20回日本未病システム学会学術総会
  • Place of Presentation: 東京都千代田区学術総合センター
• [Presentation] 糖尿病腎症治療薬としてのAGEs-DNA aptamer (2013)
  • Author(s): 深水圭，山岸昌一，甲斐田裕介，東元祐一郎，竹内正義，井上浩義，松井孝憲，奥田誠也
  • Organizer: 第28回日本糖尿病合併症学会
  • Place of Presentation: 旭川市旭川グランドホテル
• [Presentation] Lanthanum suppresses AGEs-induced osteoblastic differentiation via inhibition of RAGE-ROS-NF-κB pathway in rat vascular smooth muscle cells. (2013)
  • Author(s): Yosuke Nakayama, Kei Fukami, Sho-ichi Yamagishi, Yusuke Kaida, Ryotaro Ando, Nana Obara, Masayoshi Takeuchi, Seiji Ueda and Seiya Okuda.
  • Organizer: ERA-EDTA 50th Congress
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease (2013)
  • Author(s): Joseph George, Masayoshi Takeuchi, Mikihiko Tsutumi
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando, USA
• [Presentation] 糖尿病性腎症進展阻止をめざした次世代分子標的治療薬AGEs-aptamer の開発
  • Author(s): 甲斐田裕介，深水圭，松井孝憲，竹内正義，上田誠二，井上浩義，東元祐一郎，山岸昌一，奥田誠也
  • Organizer: 第17回日本心血管内分泌代謝学会
  • Place of Presentation: 大阪市千里ライフサイエンスセンター
• [Book] アンチエイジングのための100の質問 (2014)
  • Author(s): 竹内正義
  • Total Pages: 2
  • Publisher: メディカルレビュー社
• [Book] アンチエイジングのための100の質問 (2014)
  • Author(s): 逆井（坂井）亜紀子、竹内正義
  • Total Pages: 2
  • Publisher: メディカルレビュー社
• [Book] アンチエイジングのための100の質問 (2014)
  • Author(s): 高田尊信、竹内正義
  • Total Pages: 2
  • Publisher: メディカルレビュー社
• [Remarks] 金沢医科大学総合医学研究所・先端医療研究領域糖化制御研究分野HP
  • URL: http://mri-ages.kanazawa-med.labos.ac/one/
• [Remarks] YOUTUBE：一般向け動画サイト：「蛋白質糖化研究による加齢、生活習慣病と食生活」
  • URL: https://www.youtube.com/watch?v=elvc7eo3KJQ
• [Remarks] 糖化制御研究分野
  • URL: http://mri-ages.kanazawa-med.labos.ac/one/
• [Remarks] 一般向け動画サイト：「蛋白質糖化研究による加齢、生活習慣病と食生活」（2014/04/13）
  • URL: https://www.youtube.com/watch?v=elvc7eo3KJQ
• [Remarks] 金沢医科大学 糖化制御研究分野
  • URL: http://mri-ages.kanazawa-med.labos.ac/one/
• [Patent(Industrial Property Rights)] カスパーゼ－３の異常高分子化を抑制または抑止する物質のスクリーニング法 (2015)
  • Inventor(s): 逆井亜紀子、竹内正義
  • Industrial Property Rights Holder: 学校法人金沢医科大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-189096
  • Filing Date: 2015-09-28