Development of exercise trainings and hyperbaric oxigen preconditioning therapy for diabetic microangiopathy
| Project/Area Number |
25282165
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Nagoya Women's University |
|---|
Principal Investigator |
Kondo Hiroyo 名古屋女子大学, 家政学部, 准教授 (50333183)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
藤野 英己 神戸大学, 保健学研究科, 教授 (20278998)
石原 昭彦 京都大学, 人間・環境学研究科(研究院), 教授 (90184548)
村上 慎一郎 姫路獨協大学, 公私立大学の部局等, 教授 (30454763)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
|---|
| Keywords | 糖尿病 / 運動 / 高酸素 / 微小血管 / 毛細血管 / 微小循環 |
|---|
| Outline of Final Research Achievements |
The purpose of the present study was to explore the effects of low- and high-intensity exercise training, mild hyperbaric oxidation, and nutrition strategies on the changes of the three-dimensional capillary networks and associated angiogenic factors in the skeletal muscle of type 2 diabetes. The capillary volume and angiogenic factors in skeletal muscle were higher in the exercise trainings and hyperbaric oxidation than in the control and diabetic muscle, whereas that in the diabetic muscle was the lowest. In addition, there is no difference between the low- and high-intensity exercise, and hyperbaric oxidation in the capillary volume and the almost angiogenic factors of skeletal muscle. These results revealed that exercise and hyperbaric oxidation therapies are effective to maintain the architecture of capillary network in diabetic skeletal muscle.
|
Report
(5 results)
Research Products
(83 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Defferent Effects of Intermittent Loadig on Muscle Atrophy and Capillary Regression of Soleus Muscle in Hindlimnb-Unloaded Rats.2013
Author(s)
Tanaka M, Kanazashi M, Hirayama Y, Tanaka M, Nagatomo F, Fujita N, Kondo H, Murakami S, Ishihara A, Fujino H.
Organizer
34th Annual Meeting International Gravitational Physiology
Place of Presentation
Toyohashi, JAPAN
Related Report
-
-
-
-
-
[Presentation] Different effects of aerobic and anaerobic exercise on the capillary in the extensor digitorum longus: PGC-1α, VEGF, Flk-1 and Capillary Architecture.2013
Author(s)
Murakami S, Fujita N, Tanaka M, Morifuji T, Kanazashi M, Sakita M, Kondo H, Momota R, Ohtsuka A, Fujino H.
Organizer
Experimental Biology
Place of Presentation
Boston, USA
Related Report
-
-
[Presentation] Astaxanthin Protects Oxidative Stress and Metabolic Disorders of Atrophied Soleus Muscle in Rats.2013
Author(s)
Kanazashi M, Tanaka M, Tanaka M, Hirayama Y, Nagatomo F, Fujita N, Kondo H, Murakami S, Ishihara A, Fujino H.
Organizer
34th Annual Meeting International Gravitational Physiology
Place of Presentation
Toyohashi, JAPAN
Related Report
-
-
-
-
-
