Study on innovative nano particle drag for neutron capture therapy
Project/Area Number |
25287157
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Plasma science
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Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
SAKAKITA HAJIME 国立研究開発法人産業技術総合研究所, 電子光技術研究部門, 研究グループ長 (90357088)
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Co-Investigator(Kenkyū-buntansha) |
池原 譲 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 上級主任研究員 (10311440)
小口 治久 国立研究開発法人産業技術総合研究所, 電子光技術研究部門, 主任研究員 (20356976)
金子 俊郎 東北大学, 工学(系)研究科(研究院), 教授 (30312599)
金 載浩 国立研究開発法人産業技術総合研究所, 電子光技術研究部門, 主任研究員 (30376595)
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Research Collaborator |
ITAGAKI Hirotomo
FUJIWARA Yutaka
MINOWA Yuki
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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Keywords | プラズマ応用 / フラーレン / 癌 / 放射線 / プラズマ・核融合 / ナノチューブ・フラーレン |
Outline of Final Research Achievements |
The purpose of this study is to develop boron-containing safe drags for boron neutron capture therapy for the treatment of intractable cancer. It is possible to reduce tissue damage by the radiation, when neutrons with permeability are used for the therapy. Current boron drags have problems such as chemical stability, the toxicity of the boron, and less accumulation efficiency of drag delivery to the tumor. Therefore, following techniques were developed. i) Plasma technologies to reduce boron toxicity by encapsulating the boron into the fullerene. ii) Coating technologies the fullerene by the liposome, to deliver the drag. Hereafter, following studies will be tried; increase of encapsulating rate the boron into the fullerene, and effectiveness of produced drags by the neutron treatment.
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Academic Significance and Societal Importance of the Research Achievements |
中性子線捕捉療法は、放射線に伴う正常細胞への障害を減らすことができる。しかし、現在の中性子線捕捉用ボロン製剤は、ボロン毒性、腫瘍部への蓄積性の制御の観点等において課題がある。そこで、プラズマ技術等を駆使してボロンをフラーレン内に包含させて毒性を封じ込め、更に当該粒子を糖鎖被覆リポソームに効率良く封入させることができれば、腹腔内に転移した胃がんなどの難治性がん治療に道を拓くことになり、その意義は大きいと考えられる。
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Report
(5 results)
Research Products
(57 results)
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[Journal Article] Recent Research Activities of Innovative Plasma Technologies Group in AIST2013
Author(s)
H. Sakakita, T. Fujii, M. Fujiwara, Y. Ikehara, S. Kato, J. Kim, H. Koguchi, I. Okuda, E. Takahashi, Y. Toyoshima, S. Kiyama, Y. Hirano, T. Shimada
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Journal Title
Proc. Joint Symposium on Plasma and Electrostatic Technologies for Environmental Applications & 2nd Japan-Korea WG Meeting for Plasma Applications
Volume: PP-01
Pages: 1-2
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[Presentation] CVD synthesis of monolayer transition metal dichalcogenides2015
Author(s)
T. Takahashi, T. Kato and T. Kaneko
Organizer
7th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma-Nano Technology & Science
Place of Presentation
Nagoya University (Nagoya, Japan)
Year and Date
2015-03-30
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[Presentation] Industrial Applications using Innovative Plasma Technologies (Developments of the low energy ion beam, and studies on medical applications)2014
Author(s)
Hajime Sakakita, Yutaka Fujiwara, Yoichi Hirano, Sanae Ikehara, Yuzuru Ikehara, Jaeho Kim, Satoru Kiyama, Haruhisa Koguchi, Akihisa Nakamiya, Hiromasa Yamada, and Yusuke Yamagishi
Organizer
The 7th International Conference on Advanced Materials Development and Performance (AMDP2014)
Place of Presentation
Korea Maritime and Ocean University (Pusan, Korea)
Year and Date
2014-07-17
Related Report
Invited
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[Presentation] Industrial Applications using Innovative Plasma Technologies (Developments of the low energy ion beam, and studies on medical applications)2014
Author(s)
Hajime Sakakita, Yutaka Fujiwara, Yoichi Hirano, Sanae Ikehara, Yuzuru Ikehara, Jaeho Kim, Satoru Kiyama, Haruhisa Koguchi, Akihisa Nakamiya, Hiromasa Yamada, and Yusuke Yamagishi
Organizer
The 7th International Conference on Advanced Materials Development and Performance (AMDP2014)
Place of Presentation
Korea Maritime and Ocean University, Busan, Korea
Related Report
Invited
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[Presentation] Recent Research Activities of Innovative Plasma Technologies Group in AIST
Author(s)
H. Sakakita, T. Fujii, M. Fujiwara, Y. Ikehara, S. Kato, J. Kim, H. Koguchi, I. Okuda, E. Takahashi, Y. Toyoshima, S. Kiyama, Y. Hirano, T. Shimada
Organizer
Joint Symposium on Plasma and Electrostatic Technologies for Environmental Applications & 2nd Japan-Korea WG Meeting for Plasma Applications
Place of Presentation
Gero Synergy Center、下呂、岐阜
Related Report
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[Presentation] Introduction of Medical Plasma Equipment for the Minimally Invasive Treatment、International Conference on Flow Dynamics 2013
Author(s)
Hajime Sakakita, Yuzuru Ikehara, Jaeho Kim, Nobuyuki Shimizu, Sanae Ikehara, Hayao Nakanishi, Hiromasa Yamada, Yusuke Yamagishi, Satoru Kiyama, Akiko, Kubota, Masao Ichinose, and Toru Niwa
Organizer
International Conference on Flow Dynamics 2013
Place of Presentation
Sendai International Center, Sendai, Miyagi
Related Report
Invited
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