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Visualization of the functionala neural circuits for visual cognition

Research Project

Project/Area Number 25290009
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute of Genetics

Principal Investigator

Muto Akira  国立遺伝学研究所, 個体遺伝研究系, 助教 (00525991)

Co-Investigator(Renkei-kenkyūsha) Kawakami Koichi  国立遺伝学研究所, 個体遺伝研究系, 教授 (70195048)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Keywords捕獲行動 / 視覚系 / ゼブラフィッシュ / カルシウムイメージング / 前視蓋 / 視床下部
Outline of Final Research Achievements

We aimed to identify a neuronal population that has a specific role in visual prey detection. For this goal, first we established a genetic system in which we can introduce a genetically encoded calcium indicator GCaMP into any cell types of our interes, using the Gal4-UAS system. We examined the neuronal activity in the zebrafish larval brain to identify neurons that responded to the prey. We successfully identified a subpopulation of neurons in the pretectal area that showed specific response to paramecia in the proximity of the larva.Furthermore we demonstrated that the prey capture behavior was abolished when these neurons were ablated by either expression of a neurotoxin or two photon laser. Thus we propose that these neurons act as "prey detector" in the zebrafish.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Endothelial Ca 2+ oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo2015

    • Author(s)
      Yokota Y*, Nakajima H*(Co-first author), Wakayama Y, Muto A, Kawakami K, Fukuhara S, Mochizuki N.
    • Journal Title

      eLife

      Volume: 4

    • DOI

      10.7554/elife.08817

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prey capture in zebrafish larvae serves as a model to study cognitive functions2013

    • Author(s)
      Muto, A., and Kawakami, K.
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 7 Pages: 110-110

    • DOI

      10.3389/fncir.2013.00110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ゼブラフィッシュ捕獲行動における前視蓋―視床下部の神経回路の役割2015

    • Author(s)
      武藤 彩
    • Organizer
      第11回水生動物の神経系と行動シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genetic identification of a neural circuit for prey perception in zebrafish2015

    • Author(s)
      Muto A. and Kawakami K.
    • Organizer
      45th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      シカゴ、アメリカ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic identification of a prey detector circuit in zebrafish2015

    • Author(s)
      Muto A. and Kawakami K.
    • Organizer
      第38回 日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genetic identification of prey detector neurons in zebrafish2015

    • Author(s)
      Akira Muto
    • Organizer
      The 6th Strategic Conference of Zebrafish Investigators
    • Place of Presentation
      Pacific Grobe, CA, USA
    • Year and Date
      2015-01-17 – 2015-01-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prey perception in zebrafish larvae2014

    • Author(s)
      武藤彩
    • Organizer
      第20回小型魚類研究会
    • Place of Presentation
      東京都港区 慶應義塾大学
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Book] Zebrafish: Methods and Protocols, Second Edition.  Chapter: Calcium Imaging of Neuronal Activity in Free-Swimming Larval Zebrafish2016

    • Author(s)
      Akira Muto and Koichi Kawakami
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Genetics, Genomics and Phenomics of Fish. Chapter:Gal4 driver transgenic zebrafish: Powerful tools to study developmental biology, organogenesis and neuroscience2016

    • Author(s)
      K.Kawakami, K.Asakawa, M.Hibi, M.Itoh,A.Muto and H.Wada
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-21   Modified: 2017-05-10  

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