Anatomical and functional dissection of the central olfactory system

• Project/Area Number: 25290010
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: National Institute of Genetics
• Principal Investigator: HIRATA Tatsumi 国立遺伝学研究所, 総合遺伝研究系, 教授 (80260587)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 嗅覚系 / 誕生日タグづけシステム / トランスジェニックマウス / 誕生日依存組換え / 神経回路 / 神経発生 / 軸索ガイド / マウス

Outline of Final Research Achievements

The olfactory information is spatially represented as an “odor map” over the olfactory bulb. It is yet unclear how this map is transferred to the next level. This study aims at dissecting olfactory secondary circuits by focusing on birthdate differences of olfactory bulb neurons. We made transgenic mouse lines in which DNA recombination is induced in a neuronal birthdate-dependent manner. Using the mouse lines, I revealed that olfactory bulb neurons with different birthdates have different projection patterns.

Research Products

• [Int'l Joint Research] Max Planck Institute(Germany)
• [Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain (2015)
  • Author(s): Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 112(36) Issue: 36
  • DOI: 10.1073/pnas.1420701112
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Transcallosal projections require glycoprotein M6-dependent neurite growth and guidance. (2014)
  • Author(s): S. Mita, P. Monasterio-Schrader, U. Fünfschilling, T. Kawasaki, H. Mizuno, T. Iwasato, K.-A. Nave, H. B. Werner, and T. Hirata
  • Journal Title: Cerebral Cortex Volume: [Epub ahead of print] Issue: 11 Pages: 4111-4125
  • DOI: 10.1093/cercor/bhu129
  • Peer Reviewed
• [Journal Article] The synaptic targeting of mGluR1 by its carboxyl-terminal domain Is crucial for cerebellar function (2014)
  • Author(s): Yoshiaki Ohtani, Mariko Miyata, Kouichi Hashimoto, Toshihide Tabata, Yasushi Kishimoto, Masahiro Fukaya, Daisuke Kase, Hidetoshi Kassai, Kazuki Nakao, Tatsumi Hirata, Masahiko Watanabe, Masanobu Kano, Atsu Aiba
  • Journal Title: Journal of Neuroscience Volume: 34 Issue: 7 Pages: 2702-2712
  • DOI: 10.1523/jneurosci.3542-13.2014
  • Peer Reviewed
• [Journal Article] A common developmental plan for neocortical gene-expressing neurons in the pallium of the domestic chicken Gallus gallus domesticus and the Chinese softshell turtle Pelodiscus sinensis. (2014)
  • Author(s): I. K. Suzuki and T. Hirata
  • Journal Title: Front. Neuroanat. Volume: 8 Pages: 1-17
  • DOI: 10.3389/fnana.2014.00020
  • Peer Reviewed
• [Presentation] Evolutionary conservation of neocortical neurogenetic program in the mammals and birds. (2015)
  • Author(s): T. Hirata
  • Organizer: 9th World Congress IBRO 2015, Symposium: Evolution of cerebral cortical development
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2015-07-07
  • Int'l Joint Research / Invited
• [Presentation] Origin of the neurogenetic program in the mammalian neocortex (2015)
  • Author(s): T. Hirata
  • Organizer: 第48回日本発生生物学会 シンポジウム
  • Place of Presentation: 筑波
  • Year and Date: 2015-06-02
  • Invited
• [Presentation] Mammalian-type neurogenic potential in chick pallial neural progenitors (2013)
  • Author(s): Hirata, T.
  • Organizer: The Company of Biologists Workshop, Evolution of the Human Neocortex: How Unique Are We?,
  • Place of Presentation: Wiston House, Steyning, West Sussex, UK
  • Invited
• [Book] Evolution of Nervous Systems, 2nd edition (2016)
  • Author(s): T. Nomura and T. Hirata
  • Publisher: Elsevier
• [Remarks] 神経軸索の正常な伸長と経路選択を助ける膜タンパク質
  • URL: http://www.nig.ac.jp/Research-Highlights/1468/1520.html