Anatomical and functional dissection of the central olfactory system
| Project/Area Number |
25290010
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
HIRATA Tatsumi 国立遺伝学研究所, 総合遺伝研究系, 教授 (80260587)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 嗅覚系 / 誕生日タグづけシステム / トランスジェニックマウス / 誕生日依存組換え / 神経回路 / 神経発生 / 軸索ガイド / マウス |
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| Outline of Final Research Achievements |
The olfactory information is spatially represented as an “odor map” over the olfactory bulb. It is yet unclear how this map is transferred to the next level. This study aims at dissecting olfactory secondary circuits by focusing on birthdate differences of olfactory bulb neurons. We made transgenic mouse lines in which DNA recombination is induced in a neuronal birthdate-dependent manner. Using the mouse lines, I revealed that olfactory bulb neurons with different birthdates have different projection patterns.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon- derived GABAergic neurons in the developing mouse brain.2015
Author(s)
Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 112(36)
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Synaptic targeting of mGluR1 by carboxyl-terminal domain is crucial for cerebellar function.2014
Author(s)
Y. Ohtani, M. Miyata, K. Hashimoto, T. Tabata, Y. Kishimoto, M. Fukaya, D. Kase, H. Kassai, K. Nakao, T. Hirata, M. Watanabe, M. Kano, A. Aiba
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Journal Title
J Neurosci
Volume: 34(7)
Pages: 2702-2712
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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