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Anatomical and functional dissection of the central olfactory system

Research Project

Project/Area Number 25290010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute of Genetics

Principal Investigator

HIRATA Tatsumi  国立遺伝学研究所, 総合遺伝研究系, 教授 (80260587)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords嗅覚系 / 誕生日タグづけシステム / トランスジェニックマウス / 誕生日依存組換え / 神経回路 / 神経発生 / 軸索ガイド / マウス
Outline of Final Research Achievements

The olfactory information is spatially represented as an “odor map” over the olfactory bulb. It is yet unclear how this map is transferred to the next level. This study aims at dissecting olfactory secondary circuits by focusing on birthdate differences of olfactory bulb neurons. We made transgenic mouse lines in which DNA recombination is induced in a neuronal birthdate-dependent manner. Using the mouse lines, I revealed that olfactory bulb neurons with different birthdates have different projection patterns.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] Max Planck Institute(Germany)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain2015

    • Author(s)
      Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 112(36) Issue: 36

    • DOI

      10.1073/pnas.1420701112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transcallosal projections require glycoprotein M6-dependent neurite growth and guidance.2014

    • Author(s)
      S. Mita, P. Monasterio-Schrader, U. Fünfschilling, T. Kawasaki, H. Mizuno, T. Iwasato, K.-A. Nave, H. B. Werner, and T. Hirata
    • Journal Title

      Cerebral Cortex

      Volume: [Epub ahead of print] Issue: 11 Pages: 4111-4125

    • DOI

      10.1093/cercor/bhu129

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The synaptic targeting of mGluR1 by Its carboxyl-terminal domain is crucial for cerebellar function2014

    • Author(s)
      Yoshiaki Ohtani, Mariko Miyata, Kouichi Hashimoto, Toshihide Tabata, Yasushi Kishimoto, Masahiro Fukaya, Daisuke Kase, Hidetoshi Kassai, Kazuki Nakao, Tatsumi Hirata, Masahiko Watanabe, Masanobu Kano, Atsu Aiba
    • Journal Title

      Journal of Neuroscience

      Volume: 34 Issue: 7 Pages: 2702

    • DOI

      10.1523/jneurosci.3542-13.2014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A common developmental plan for neocortical gene-expressing neurons in the pallium of the domestic chicken Gallus gallus domesticus and the Chinese softshell turtle Pelodiscus sinensis.2014

    • Author(s)
      I. K. Suzuki and T. Hirata
    • Journal Title

      Front. Neuroanat.

      Volume: 8 Pages: 1-17

    • DOI

      10.3389/fnana.2014.00020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Evolutionary conservation of neocortical neurogenetic program in the mammals and birds.2015

    • Author(s)
      T. Hirata
    • Organizer
      9th World Congress IBRO 2015, Symposium: Evolution of cerebral cortical development
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2015-07-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Origin of the neurogenetic program in the mammalian neocortex2015

    • Author(s)
      T. Hirata
    • Organizer
      第48回日本発生生物学会 シンポジウム
    • Place of Presentation
      筑波
    • Year and Date
      2015-06-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Mammalian-type neurogenic potential in chick pallial neural progenitors2013

    • Author(s)
      Hirata, T.
    • Organizer
      The Company of Biologists Workshop, Evolution of the Human Neocortex: How Unique Are We?,
    • Place of Presentation
      Wiston House, Steyning, West Sussex, UK
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Evolution of Nervous Systems, 2nd edition2016

    • Author(s)
      T. Nomura and T. Hirata
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report
  • [Remarks] 神経軸索の正常な伸長と経路選択を助ける膜タンパク質

    • URL

      http://www.nig.ac.jp/Research-Highlights/1468/1520.html

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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