| Co-Investigator(Kenkyū-buntansha) |
佐々木 惇 埼玉医科大学, 医学部, 教授 (80225862)
伊古田 勇人 群馬大学, 大学院医学系研究科, 准教授 (90420116)
信澤 純人 群馬大学, 大学院医学系研究科, 助教 (80635318)
村上 孝 埼玉医科大学, 医学部, 教授 (00326852)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Glioblastoma is one of common brain tumors and its clinical outcome is usually miserable. Glioblastoma often shows abnormal activation of epidermal growth factor receptor (EGFR) signaling pathway, and the abnormality is believed to be closely linked to tumorigenesis. We developed a novel strain of transgenic rats designed to show constitutional overexpression of v-erbB, a viral homolog of EGFR, and the rat was demonstrated to give rise to brain tumors spontaneously after long-term latency. We performed various experiments using the model rats, together with diversified analyses human brain tumors, and obtained several curious results.
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