Negative regulation of axonal myelination
| Project/Area Number |
25290028
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Yamauchi Junji 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 室長 (20335483)
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| Research Collaborator |
KAWAHARA KAZUKO 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 研究補助員
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | ミエリン形成 / 脱ミエリン現象 / 抑制シグナル / 促進シグナル / サイトヘジン / Arf6 / シグナル伝達分子 / 脱ミエリン疾患 / ミエリン / 髄鞘 / サイトヘジン1 / サイトヘジン2 / ACAP2 / 髄鞘髄鞘 / 脱髄 / 創薬 / シグナル伝達 / 創薬標的 / ミエリン形成促進 / ミエリン形成抑制 / 低分子量GTP結合蛋白質 / 増殖因子受容体 / 障害後再生 / 再生プログラム / 発生プログラム / 髄鞘発生 / 髄鞘形成 / 脱髄改善 / 交換因子 / GTPアーゼ活性化蛋白質 / Arfファミリー / Rhoファミリー / ミエリン発生 / ミエリン形成の抑制 / ミエリン形成の促進 / シグナル伝達因子 / 創薬標的分子 / 創薬標的候補分子 / 治療標的候補分子 |
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| Outline of Final Research Achievements |
It is believed that myelination in mammals is regulated by positive and negative signaling molecules; however, it remains to be understood what and how molecule controls myelination. Here we investigate inhibitory signaling for myelination in the peripheral nervous system. We clarify that the molecular pathway controlled by cytohesin regulates myelination. We also find that this pathway is composed of two reciprocal signaling pathways. Further studies allow us not only to understand the detailed mechanim of myelination but also to identify a potential therapeutic target for dismyelination desieases.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination.2015
Author(s)
Yuki Miyamoto, Tomohiro Torii, Shuji Takada, Nobuhiko Ohno, Yurika Saitoh, Kazuaki Nakamura, Akihito Ito, Toru Ogata, Nobuo Terada, Akito Tanoue, and Junji Yamauchi
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Journal Title
Mol. Biol. Cell
Volume: 26
Issue: 19
Pages: 3489-3503
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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