| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
|---|
| Outline of Final Research Achievements |
Cellular senescence is the state of essentially irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli and is therefore considered to act as an important tumor suppression mechanism. However, the imposition of cellular senescence is also associated with the increasing expression and secretion of inflammatory and pro-proliferative factors. This phenotype, termed the senescence-associated secretory phenotype (SASP), contributes positively and negatively to cancer development depending on the biological context. To understand the tumour promotion effect of secretory factors from senescent cells, we tried to identify various secretory factors and found that exosome secretion is significantly increased in senescent cells. We also discovered that exosome from senescent cells plays as tumour promotion factors, which activates DNA damage signalling in normal human cells.
|
