Analysis of tumor promotion factors secreted from senescent cells
| Project/Area Number |
25290046
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Takahashi Akiko 公益財団法人がん研究会, その他部局等, 研究員 (60380052)
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| Research Collaborator |
OKADA Ryo
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 細胞老化 / がん抑制機構 / SASP |
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| Outline of Final Research Achievements |
Cellular senescence is the state of essentially irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli and is therefore considered to act as an important tumor suppression mechanism. However, the imposition of cellular senescence is also associated with the increasing expression and secretion of inflammatory and pro-proliferative factors. This phenotype, termed the senescence-associated secretory phenotype (SASP), contributes positively and negatively to cancer development depending on the biological context. To understand the tumour promotion effect of secretory factors from senescent cells, we tried to identify various secretory factors and found that exosome secretion is significantly increased in senescent cells. We also discovered that exosome from senescent cells plays as tumour promotion factors, which activates DNA damage signalling in normal human cells.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice2015
Author(s)
Seidai Sato, Yuka Kawamata, Akiko Takahashi, Yoshinori Imai, Aki Hanyu, Atsushi Okuma, Masaki Takasugi, Kimi Yamakoshi, Hiroyuki Sorimachi, Hiroaki Kanda, Yuichi Ishikawa, Saburo Sone, Yasuhiko Nishioka, Naoko Ohtani and Eiji Hara
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Journal Title
Nature communications
Volume: 6
Issue: 1
Pages: 7035-7035
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Crosstalk between the RB-pathway and AKT signalling forms a Quiescence-Senescence switch.2014
Author(s)
Imai, Y., Takahashi, A., Hanyuu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N., Hara, E.
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Journal Title
Cell Reports
Volume: 7
Issue: 1
Pages: 194-207
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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