Development of novel CAR-T cell therapy against cancer
| Project/Area Number |
25290057
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAMADA Koji 山口大学, 医学(系)研究科(研究院), 教授 (00615841)
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| Co-Investigator(Kenkyū-buntansha) |
SAKODA Yukimi 山口大学, 大学院医学系研究科, 助教 (30629754)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | がん免疫 / CAR-T細胞 / 免疫細胞療法 / 遺伝子改変技術 / がん免疫療法 / 遺伝子改変Ｔ細胞 |
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| Outline of Final Research Achievements |
In this project, we explored anti-tumor therapeutic potential of novel CAR (chimeric antigen receptor)-T cell approach which combines FITC (fluorescein isothiocyanate)-labeled anti-tumor antibodies and anti-FITC CAR-T cells. Our studies demonstrated that the novel approach induces potent cytotoxic activity against tumor cells expressing multiple target molecules, and those harboring heterogeneous antigen expressions. In addition, the novel approach inhibits tumor growth by targeting neo-vasculature in tumor tissues. These results thus indicate superior anti-tumor effects and potent applicability of anti-FITC CAR-T cells as a next generation of cancer immunotherapy.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion.2016
Author(s)
Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
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Journal Title
Cancer Sci.
Volume: 107(4)
Issue: 4
Pages: 398-406
DOI
Related Report
Peer Reviewed
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[Journal Article] The SALM5-HVEM interaction limits inflammation and contributes to immune privilege in the CNS.2016
Author(s)
Zhu Y, Yao S, Augustine MM, Xu H, Wang J, Sun J, Broadwater M, Ruff W, Luo L, Zhu G, Tamada K, Chen L.
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Journal Title
Science Advances.
Volume: in press
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial.2015
Author(s)
Maeda Y, Yoshimura K, Matsui H, Shindo Y, Tamesa T, Tokumitsu Y, Hashimoto N, Tokuhisa Y, Sakamoto K, Sakai K, Suehiro Y, Hinoda Y, Tamada K, Yoshino S, Hazama S, Oka M.
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Journal Title
Cancer Immunol. Immunother.
Volume: 64(8)
Issue: 8
Pages: 1047-56
DOI
Related Report
Peer Reviewed
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[Journal Article] B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets.2015
Author(s)
Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L.
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Journal Title
PLoS One
Volume: 10(6)
Issue: 6
Pages: e0130126-e0130126
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor.2015
Author(s)
Shindo Y, Yoshimura K, Kuramasu A, Watanabe Y, Ito H, Kondo T, Oga A, Ito H, Yoshino S, Hazama S, Tamada K, Yagita H, Oka M.
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Journal Title
Anticancer Res.
Volume: 35
Pages: 129-36
Related Report
Peer Reviewed
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[Journal Article] A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population.2014
Author(s)
Watanabe Y, Yoshimura K, Yoshikawa K, Tsunedomi R, Shindo Y, Matsukuma S, Maeda N, Kanekiyo S, Suzuki N, Kuramasu A, Sonoda K, Tamada K, Kobayashi S, Saya H, Hazama S and Oka M
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Journal Title
Int J Oncol
Volume: 45
Issue: 5
Pages: 1857-1866
DOI
Related Report
Peer Reviewed / Open Access
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