Regulation of gene expression by the cytoplasmic germ granules in primordial germ cells
| Project/Area Number |
25290076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
System genome science
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| Research Institution | Kobe University |
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Principal Investigator |
INOUE KUNIO 神戸大学, 理学(系)研究科(研究院), 教授 (40252415)
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| Research Collaborator |
HOSHIJIMA Kazuyuki 米国ユタ大学, 助教
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 生殖細胞 / RNA / ゲノム情報 |
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| Outline of Final Research Achievements |
The mechanism underlying how germ cell-specific gene expression is regulated by the cytoplasmic determinant "germ granules" that is maternally supplied remains to be elucidated. In this study, we performed RNA-seq analyses of the wild type and germ cell-deficient embryos and identified many candidates that may act in germ cell-specific transcriptional regulation. In addition, we showed that a germ cell-specific RNA-binding protein DND has the ability to repress translation of target mRNAs in zebrafish.
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Report
(4 results)
Research Products
(9 results)
