The function of histone demethylase JMJD1A as a signal-sensing scaffold
| Project/Area Number |
25291002
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Molecular biology
|
|---|
| Research Institution | Gunma University (2016-2017)
The University of Tokyo (2013-2015) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAKAI JURO 東京大学, 先端科学技術研究センター, 教授 (80323020)
ABURATANI HIROYUKI 東京大学, 先端科学技術研究センター, 教授 (10202657)
FUJITA TOSHIRO 東京大学, 先端科学技術研究センター, 特任研究員 (10114125)
KAWAMURA TAKESHI 東京大学, アイソトープ総合センター, 准教授 (70306835)
|
|---|
| Project Period (FY) |
2013-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
|
|---|
| Keywords | エピゲノム / クロマチン構造 / ヒストン脱メチル化酵素 / JMJD1A / 熱産生 / 褐色脂肪 / クロマチン再構成 / エピジェネティクス / 糖脂質代謝 / クロマチン / Pparg / アドレナリン受容体 / 寒冷 / ホスファターゼ / 褐色脂肪細胞 / UCP1 / 核内受容体 / ＪＭＪＤ１Ａ |
|---|
| Outline of Final Research Achievements |
Regulating metabolic diseases including diabetes mellitus and obesity is an important research issue for human health. We previously elucidated that the mouse lucking histone demethylase JMJD1A is obesity, diabetes, and cold-sensitive. In this study, we elucidated that JMJD1A is phosphorylated at S265 by β-adrenergic stimulation in response to acute cold exposure. Phosphorylated JMJD1A forms complex with SWI/SNF chromatin remodeler and nuclear transcription factor PPARγ. The P-JMJD1A-SWI/SNF-PPARγ complex induces enhancer-promoter proximity by forming long-range chromatin loop and, in turn, regulates thermogenic gene expression. Thus, phosphorylated histone demethylase JMJD1A regulates metabolic gene expression by mediating long-range genomic interactions in response to β-adrenergic stimulation.
|
Report
(6 results)
Research Products
(43 results)
-
-
-
[Journal Article] Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.2017
Author(s)
Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.
-
Journal Title
PLoS Genet.
Volume: 13(8)
Issue: 8
Pages: 1-23
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
[Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis2015
Author(s)
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.
-
Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.2015
Author(s)
Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., Sakai, J.
-
Journal Title
Molecular Cell
Volume: 60
Issue: 4
Pages: 584-596
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis2015
Author(s)
Abe Y., Rozqie R., Matsumura Y., Kawamura T., Nakaki R., Tsurutani Y., Tanimura-Inagaki K., Shiono A., Magoori K., Nakamura K., Ogi S., Kajimura S., Kimura H., Tanaka T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Inagaki T.*, Sakai J.* (*Corresponding author)
-
Journal Title
Nature Communications
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis.2015
Author(s)
Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J
-
Journal Title
J Biol Chem
Volume: 290
Issue: 7
Pages: 4163-77
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] PPARβ/δ activation of CD300a controls intestinal immunity.2014
Author(s)
Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
-
Journal Title
Sci Rep
Volume: 4
Issue: 1
Pages: 5412-5412
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
