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The function of histone demethylase JMJD1A as a signal-sensing scaffold

Research Project

Project/Area Number 25291002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Molecular biology
Research InstitutionGunma University (2016-2017)
The University of Tokyo (2013-2015)

Principal Investigator

INAGAKI TAKESHI  群馬大学, 生体調節研究所, 教授 (10507825)

Co-Investigator(Renkei-kenkyūsha) SAKAI JURO  東京大学, 先端科学技術研究センター, 教授 (80323020)
ABURATANI HIROYUKI  東京大学, 先端科学技術研究センター, 教授 (10202657)
FUJITA TOSHIRO  東京大学, 先端科学技術研究センター, 特任研究員 (10114125)
KAWAMURA TAKESHI  東京大学, アイソトープ総合センター, 准教授 (70306835)
Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywordsエピゲノム / クロマチン構造 / ヒストン脱メチル化酵素 / JMJD1A / 熱産生 / 褐色脂肪 / クロマチン再構成 / エピジェネティクス / 糖脂質代謝 / クロマチン / Pparg / アドレナリン受容体 / 寒冷 / ホスファターゼ / 褐色脂肪細胞 / UCP1 / 核内受容体 / JMJD1A
Outline of Final Research Achievements

Regulating metabolic diseases including diabetes mellitus and obesity is an important research issue for human health. We previously elucidated that the mouse lucking histone demethylase JMJD1A is obesity, diabetes, and cold-sensitive. In this study, we elucidated that JMJD1A is phosphorylated at S265 by β-adrenergic stimulation in response to acute cold exposure. Phosphorylated JMJD1A forms complex with SWI/SNF chromatin remodeler and nuclear transcription factor PPARγ. The P-JMJD1A-SWI/SNF-PPARγ complex induces enhancer-promoter proximity by forming long-range chromatin loop and, in turn, regulates thermogenic gene expression. Thus, phosphorylated histone demethylase JMJD1A regulates metabolic gene expression by mediating long-range genomic interactions in response to β-adrenergic stimulation.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (43 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 10 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (22 results) (of which Int'l Joint Research: 1 results,  Invited: 15 results) Remarks (8 results)

  • [Int'l Joint Research] カリフォルニア大学サンフランシスコ校(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カルフォルニア大学サンフランシスコ校(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.2017

    • Author(s)
      Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.
    • Journal Title

      PLoS Genet.

      Volume: 13(8) Issue: 8 Pages: 1-23

    • DOI

      10.1371/journal.pgen.1006950

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulations of Adipocyte Phenotype and Obesity by IRX3. Positive or Negative?2017

    • Author(s)
      Inagaki T.
    • Journal Title

      eBioMedicine

      Volume: 24 Pages: 7-8

    • DOI

      10.1016/j.ebiom.2017.09.032

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] T1R3 homomeric sweet taste receptor regulates adipogenesis through Gas-mediated microtubules disassembly and Rho activation in 3T3-L1 cells2017

    • Author(s)
      Y. Masubuchi, Y. Nakagawa, J. Medina, M. Nagasawa, I. Kojima, M. M. Rasenick, T. Inagaki, H. Shibata
    • Journal Title

      PLOS ONE

      Volume: - Issue: 5 Pages: e0176841-e0176841

    • DOI

      10.1371/journal.pone.0176841

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transcriptional and epigenetic control of brown and beige adipose cell fate and function2016

    • Author(s)
      Inagaki T, Sakai J, Kajimura S.
    • Journal Title

      Nature Reviews Molecular Cell Biology

      Volume: 17 Issue: 8 Pages: 480-495

    • DOI

      10.1038/nrm.2016.62

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transcriptional and epigenetic control of brown and beige adipocyte cell fate and function2016

    • Author(s)
      Inagaki T., Sakai J, Kajimura S.*
    • Journal Title

      Nature Reviews Molecular Cell Biology

      Volume: 掲載確定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis2015

    • Author(s)
      Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 1-14

    • DOI

      10.1038/ncomms8052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD.2015

    • Author(s)
      Inagaki T.*
    • Journal Title

      Front. Endocrinol. (Lausanne)

      Volume: 6 Pages: 147-147

    • DOI

      10.3389/fendo.2015.00147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.2015

    • Author(s)
      Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., Sakai, J.
    • Journal Title

      Molecular Cell

      Volume: 60 Issue: 4 Pages: 584-596

    • DOI

      10.1016/j.molcel.2015.10.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis2015

    • Author(s)
      Abe Y., Rozqie R., Matsumura Y., Kawamura T., Nakaki R., Tsurutani Y., Tanimura-Inagaki K., Shiono A., Magoori K., Nakamura K., Ogi S., Kajimura S., Kimura H., Tanaka T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Inagaki T.*, Sakai J.* (*Corresponding author)
    • Journal Title

      Nature Communications

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis.2015

    • Author(s)
      Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 7 Pages: 4163-77

    • DOI

      10.1074/jbc.m114.626929

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PPARβ/δ activation of CD300a controls intestinal immunity.2014

    • Author(s)
      Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 5412-5412

    • DOI

      10.1038/srep05412

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 肝の体性幹様細胞を機能肝細胞に効率よく分化誘導する補助肝臓の作成2017

    • Author(s)
      小暮公孝、柴田 宏、長澤雅裕、中川祐子、李龍飛、小島至、稲垣 毅、根本雅明、石崎利、桑野博行、幕内雅敏
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マクロファージに発現するT1R3ホモマー甘味受容体の機能2017

    • Author(s)
      李龍飛、メディナ ヨハン、長澤雅裕、稲垣 毅、柴田 宏
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒストン修飾酵素複合体形成による遺伝子発現調節2017

    • Author(s)
      稲垣 毅、阿部陽平、Rozqie Royhan、岩崎 聡、松村欣宏、児玉龍彦、油谷浩幸、酒井寿郎
    • Organizer
      第11回日本エピジェネティクス研究会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪細胞の機能・性質を制御するエピゲノム機構2017

    • Author(s)
      稲垣 毅
    • Organizer
      第16回生体機能研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪細胞の性質決定に関わるヒストンメチル化制御機構2017

    • Author(s)
      稲垣 毅
    • Organizer
      第40回分子生物学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストン脱メチル化酵素JMJD1Aの肥満、糖尿病における機能解析2017

    • Author(s)
      稲垣 毅、酒井寿郎
    • Organizer
      第31回日本糖尿病・肥満動物学会年次学術集会(シンポジウム)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 転写調節因子とクロマチン構造変化を介した糖脂質代謝制御機構の解明2016

    • Author(s)
      稲垣 毅
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      京都国際会館 (京都府)
    • Year and Date
      2016-04-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 転写調節因子とクロマチン構造変化を介した糖脂質代謝制御機構の解明2016

    • Author(s)
      稲垣 毅
    • Organizer
      第89回 日本内分泌学会学術総会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヒストン修飾酵素による脂肪細胞制御2016

    • Author(s)
      稲垣 毅、阿部陽平、Rozqie Royhan、松村欣宏、岩崎聡、梶村真吾、田中十志也、児玉龍彦、油谷浩幸、酒井寿郎
    • Organizer
      第59回日本糖尿病学会年次学術集会(シンポジウム)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] JMJD1A複合体による熱産生のエピゲノム制御機構2016

    • Author(s)
      稲垣 毅、阿部陽平、Rozqie Royhan、松村欣宏、仲木竜、川村猛、梶村真吾、児玉龍彦、油谷浩幸、酒井寿郎
    • Organizer
      第39回日本分子生物学会年会(シンポジウム)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 寒冷刺激に応答するクロマチン構造の調節機構2015

    • Author(s)
      稲垣 毅
    • Organizer
      Adiposcience in Hiroshima 2nd
    • Place of Presentation
      Oriental Hotel Hiroshima (広島県)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Regulation of Higher-order Chromatin Structure during Thermogenesis in Brown Adipocytes2015

    • Author(s)
      稲垣 毅、阿部 陽平、Royhan Rozqie、松村 欣宏、梶村 真吾、酒井 寿郎
    • Organizer
      The 46th NIPS International Symposium
    • Place of Presentation
      Nagoya Congress Center (愛知県)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エピゲノム研究から見た一卵性双生児2015

    • Author(s)
      稲垣 毅
    • Organizer
      第 16 回日本内分泌学会関東甲信越支部学術集会
    • Place of Presentation
      幕張メッセ国際会議場 (千葉県)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アディポバイオロジーを制御するヒストン脱メチル化酵素JMJD1Aの修飾シグナル2015

    • Author(s)
      稲垣 毅、阿部 陽平、Royhan Rozqie、松村 欣宏、梶村 真吾、児玉 龍彦、油谷 浩幸、酒井 寿郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関市民会館 (山口県)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脂肪細胞における新規エピゲノム制御機構2015

    • Author(s)
      稲垣毅、阿部陽平、Rozqie Royhan、松村欣宏、川村猛、仲木竜、鶴谷悠也、谷村恭子、田中十志也、児玉龍彦、油谷浩幸、酒井寿郎
    • Organizer
      第52回日本臨床分子医学会学術集会
    • Place of Presentation
      京都みやこめっせ (京都府)
    • Year and Date
      2015-04-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脂肪細胞における新規エピゲノム制御機構2015

    • Author(s)
      稲垣毅、阿部陽平、Rozqie Royhan、松村欣宏、川村猛、仲木竜、鶴谷悠也、谷村恭子、田中十志也、児玉龍彦、油谷浩幸、酒井寿郎
    • Organizer
      第52回日本臨床分子医学会学術集会
    • Place of Presentation
      京都みやこメッセ
    • Year and Date
      2015-04-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] FBXL10によるエピゲノム複合体を介した脂肪細胞分化調節機構2014

    • Author(s)
      4.稲垣 毅、岩崎 聡、松村欣宏、川村 猛、阿部陽平、吉田文乃、中村加奈子、馬郡健太、仲木 竜、田中十志也、児玉龍彦、油谷浩幸、酒井寿郎
    • Organizer
      第37回日本分子生物学会年会 (ワークショップ)
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] エネルギー代謝を制御するJMJD1Aによる新規のエピゲノム制御機構2014

    • Author(s)
      稲垣 毅
    • Organizer
      第14回 Islet Biology 研究会
    • Place of Presentation
      東京都千代田区都市センター
    • Year and Date
      2014-08-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] JMJDIA Regulates Metabolic Gene Expression by Mediating Long-Range Genomic Interactions in Response to β-Adrenergic Stimulation2014

    • Author(s)
      稲垣 毅
    • Organizer
      第46回日本動脈硬化学会総会・学術集会 (English session)
    • Place of Presentation
      東京都新宿区京王プラザホテル
    • Year and Date
      2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulation of energy expenditure mediated by post-transcriptional modifications of Jmjd1a

    • Author(s)
      稲垣毅、阿部陽平、鶴谷悠也、ロイハンロズキ、川村猛、、松村欣宏、酒井寿郎
    • Organizer
      第10回インスリン抵抗性とメタボリックシンドローム研究会
    • Place of Presentation
      東京都新宿区
    • Related Report
      2013 Annual Research Report
  • [Presentation] エピゲノムと核内受容体を介した代謝調節

    • Author(s)
      稲垣 毅
    • Organizer
      糖尿病・内分泌ステップアップセミナー2013
    • Place of Presentation
      長野県松本市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Fbxl10 controls adipogenesis through inhibiting clonal expansion by forming an epigenetic regulator complex

    • Author(s)
      稲垣毅、岩崎聡、川村猛、阿部陽平、吉田文乃、中村加奈子、馬郡健太、田中十志也、松村欣宏、酒井寿郎
    • Organizer
      International Symposium on Transcriptional and Metabolism
    • Place of Presentation
      兵庫県淡路島
    • Related Report
      2013 Annual Research Report
  • [Remarks] 群馬大学生体調節研究所

    • URL

      http://www.imcr.gunma-u.ac.jp

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 群馬大学生体調節研究所代謝エピジェネティクス分野

    • URL

      http://epigenetics.imcr.gunma-u.ac.jp/en/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 稲垣毅 東京大学代謝医学分野酒井研究室

    • URL

      http://www.mm.rcast.u-tokyo.ac.jp/member/inagaki.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター 研究者プロフィール

    • URL

      http://www.rcast.u-tokyo.ac.jp/ja/people/staff-inagaki_takeshi.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] LSBM 稲垣毅

    • URL

      http://www.lsbm.org/staff/inagaki.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 稲垣毅 東京大学代謝医学分野酒井研究室

    • URL

      http://www.mm.rcast.u-tokyo.ac.jp/member/inagaki.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター 研究者プロフィール

    • URL

      http://www.rcast.u-tokyo.ac.jp/ja/people/staff-inagaki_takeshi.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] LSBM 稲垣毅

    • URL

      http://www.lsbm.org/staff/inagaki.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-21  

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