| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Mice deficient of polydom, a newly identified integrin alpha9beta1 ligand, were generated to study the function of polydom. We found that i) polydom was secreted from mesenchymal cells and deposited around lymphatic vessels; ii) the lymphatic plexus failed to remodel into collecting lymphatic vessels in polydom-deficient mice and thereby died immediately after birth due to severe edema; iii) the expression of Foxc2, a transcription factor involved in lymphatic vessel remodeling, was reduced in polydom-deficient mice; iv) polydom was capable of binding to angiopoietin-2 that has been known to regulate lymphangiogenesis. These results indicate that polydom regulates lymphatic vessel remodeling through binding to angiopoietin-2, thereby promoting the expression of Foxc2.
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